EC number:3.5.4.5

Enzyme

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     3. Hydrolases
        3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
            3.5.4 In cyclic amidines
ID:3.5.4.5
Description:Cytidine deaminase.
Alternative Name: Cytosine nucleoside deaminase.
Cytidine aminohydrolase.
(Deoxy)cytidine deaminase.
Prosite: PDOC00702;
PDB:
PDBScop
1VQ2 8030788; 8043167;
1WKQ 8029378; 8041757; 8029378; 8041757;
1TIY 8029378; 8041757; 8029378; 8041757;
2FR6 8028924; 8041303; 8028924; 8041303; 8028924; 8041303; 8028924; 8041303;
2FR5 8028924; 8041303; 8028924; 8041303; 8028924; 8041303; 8028924; 8041303;
 » show all
Cath: 3.40.140.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 3.5.4.5
BRENDA Enzyme Link: BRENDA 3.5.4.5
KEGG Enzyme Link: KEGG3.5.4.5
BioCyc Enzyme Link: BioCyc 3.5.4.5
ExPASy Enzyme Link: ExPASy3.5.4.5
EC2PDB Enzyme Link: EC2PDB 3.5.4.5
ExplorEnz Enzyme Link: ExplorEnz 3.5.4.5
PRIAM enzyme-specific profiles Link: PRIAM 3.5.4.5
IntEnz Enzyme Link: IntEnz 3.5.4.5
MEDLINE Enzyme Link: MEDLINE 3.5.4.5

EC number:3.5.4.5

MSA:

3.5.4.5;
Phylogenetic Tree:

3.5.4.5;
Uniprot:
M-CSA:
RHEA:16069 cytidine + H(+) + H2O = NH4(+) + uridine
RULE(radius=1) [*:1]:[n;H0;+0:2]:[c;H0;+0:3](:[*:4])-[NH2;+0:5].[H+;H0:6].[OH2;+0:7]>>[*:1]:[nH;+0:2]:[c;H0;+0:3](:[*:4])=[O;H0;+0:7].[NH3;+0:5]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
The structure of the cytidine deaminase-product complex provides evidence for efficient proton transfer and ground-state destabilization.Xiang S, Short SA, Wolfenden R, Carter CW Jr1997 Apr 229125497
Human cytidine deaminase: purification of enzyme, cloning, and expression of its complementary DNA.Laliberté J, Momparler RL1994 Oct 157923172
Chromosomal location, cloning and nucleotide sequence of the Bacillus subtilis cdd gene encoding cytidine/deoxycytidine deaminase.Song BH, Neuhard J1989 Apr2526291
Cloning, expression, and purification of cytidine deaminase from Arabidopsis thaliana.Vincenzetti S, Cambi A, Neuhard J, Schnorr K, Grelloni M, Vita A1999 Feb10024464
RHEA:13433 2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+)
RULE(radius=1) [*:1]:[n;H0;+0:2]:[c;H0;+0:3](:[*:4])-[NH2;+0:5].[H+;H0:6].[OH2;+0:7]>>[*:1]:[nH;+0:2]:[c;H0;+0:3](:[*:4])=[O;H0;+0:7].[NH3;+0:5]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Human cytidine deaminase: purification of enzyme, cloning, and expression of its complementary DNA.Laliberté J, Momparler RL1994 Oct 157923172
Chromosomal location, cloning and nucleotide sequence of the Bacillus subtilis cdd gene encoding cytidine/deoxycytidine deaminase.Song BH, Neuhard J1989 Apr2526291
The wheat leaf phosphatases. II. Pathways of hydrolysis of some nucleotides at pH 5.5.ROBERTS DW1956 Sep13366999
Cloning, expression, and purification of cytidine deaminase from Arabidopsis thaliana.Vincenzetti S, Cambi A, Neuhard J, Schnorr K, Grelloni M, Vita A1999 Feb10024464