EC number:3.5.99.10

Enzyme

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     3. Hydrolases
        3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
            3.5.99 In other compounds
ID:3.5.99.10
Description:2-iminobutanoate/2-iminopropanoate deaminase.
Alternative Name: Enamine/imine deaminase.
Cath: 3.20.20.10; 3.30.1330.40; 3.30.1330.90; 3.40.1020.10; 3.40.640.10; 3.90.1150.10; 2.40.37.20; 3.40.50.1100;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 3.5.99.10
BRENDA Enzyme Link: BRENDA 3.5.99.10
KEGG Enzyme Link: KEGG3.5.99.10
BioCyc Enzyme Link: BioCyc 3.5.99.10
ExPASy Enzyme Link: ExPASy3.5.99.10
EC2PDB Enzyme Link: EC2PDB 3.5.99.10
ExplorEnz Enzyme Link: ExplorEnz 3.5.99.10
PRIAM enzyme-specific profiles Link: PRIAM 3.5.99.10
IntEnz Enzyme Link: IntEnz 3.5.99.10
MEDLINE Enzyme Link: MEDLINE 3.5.99.10

EC number:3.5.99.10

MSA:

3.5.99.10;
Phylogenetic Tree:

3.5.99.10;
Uniprot:
M-CSA:
RHEA:40671 2-iminopropanoate + H2O = NH4(+) + pyruvate
RULE(radius=1) [*:1]-[C;H0;+0:2](-[*:3])=[NH;+0:4].[OH2;+0:5]>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:5].[NH3;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Bacterial L-serine dehydratases: a new family of enzymes containing iron-sulfur clusters.Grabowski R, Hofmeister AE, Buckel W1993 Aug8236444
L-serine dehydratase from rat liver. Purification and some properties.Simon D, Hoshino J, Kröger H1973 Sep 154750769
Conserved YjgF protein family deaminates reactive enamine/imine intermediates of pyridoxal 5'-phosphate (PLP)-dependent enzyme reactions.Lambrecht JA, Flynn JM, Downs DM2012 Jan 2722094463
Crystal structure of serine dehydratase from rat liver.Yamada T, Komoto J, Takata Y, Ogawa H, Pitot HC, Takusagawa F2003 Nov 1114596599
RHEA:39975 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)
RULE(radius=1) [*:1]-[C;H0;+0:2](-[*:3])=[NH;+0:4].[OH2;+0:5]>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:5].[NH3;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Arabidopsis and maize RidA proteins preempt reactive enamine/imine damage to branched-chain amino acid biosynthesis in plastids.Niehaus TD, Nguyen TN, Gidda SK, ElBadawi-Sidhu M, Lambrecht JA, McCarty DR, Downs DM, Cooper AJ, Fiehn O, Mullen RT, Hanson AD2014 Jul25070638
Conserved YjgF protein family deaminates reactive enamine/imine intermediates of pyridoxal 5'-phosphate (PLP)-dependent enzyme reactions.Lambrecht JA, Flynn JM, Downs DM2012 Jan 2722094463