EC number:3.5.99.2
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.5 Acting on carbon-nitrogen bonds, other than peptide bonds |
| 3.5.99 In other compounds |
| ID: | 3.5.99.2 |
|---|---|
| Description: | Aminopyrimidine aminohydrolase. |
| Alternative Name: |
Thiaminase II. Thiaminase. |
| Cath: | 1.20.910.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.5.99.2 |
| BRENDA Enzyme Link: | BRENDA 3.5.99.2 |
| KEGG Enzyme Link: | KEGG3.5.99.2 |
| BioCyc Enzyme Link: | BioCyc 3.5.99.2 |
| ExPASy Enzyme Link: | ExPASy3.5.99.2 |
| EC2PDB Enzyme Link: | EC2PDB 3.5.99.2 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.5.99.2 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.5.99.2 |
| IntEnz Enzyme Link: | IntEnz 3.5.99.2 |
| MEDLINE Enzyme Link: | MEDLINE 3.5.99.2 |
| RHEA:31799 | 4-amino-5-aminomethyl-2-methylpyrimidine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+) |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[NH2;+0:3].[OH2;+0:4]>>[*:1]-[CH2;+0:2]-[OH;+0:4].[NH3;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Salvage of the thiamin pyrimidine moiety by plant TenA proteins lacking an active-site cysteine. | Zallot R, Yazdani M, Goyer A, Ziemak MJ, Guan JC, McCarty DR, de Crécy-Lagard V, Gerdes S, Garrett TJ, Benach J, Hunt JF, Shintani DK, Hanson AD | 2014 Oct 1 | 25014715 |
| Structure of trifunctional THI20 from yeast. | French JB, Begley TP, Ealick SE | 2011 Sep | 21904031 |
| Structural and mutational analysis of TenA protein (HP1287) from the Helicobacter pylori thiamin salvage pathway - evidence of a different substrate specificity. | Barison N, Cendron L, Trento A, Angelini A, Zanotti G | 2009 Nov | 19780837 |
| Mutagenesis studies on TenA: a thiamin salvage enzyme from Bacillus subtilis. | Jenkins AL, Zhang Y, Ealick SE, Begley TP | 2008 Feb | 18054064 |
| A new thiamin salvage pathway. | Jenkins AH, Schyns G, Potot S, Sun G, Begley TP | 2007 Aug | 17618314 |
| The 2.35 A structure of the TenA homolog from Pyrococcus furiosus supports an enzymatic function in thiamine metabolism. | Benach J, Edstrom WC, Lee I, Das K, Cooper B, Xiao R, Liu J, Rost B, Acton TB, Montelione GT, Hunt JF | 2005 May | 15858269 |
| Structural characterization of the regulatory proteins TenA and TenI from Bacillus subtilis and identification of TenA as a thiaminase II. | Toms AV, Haas AL, Park JH, Begley TP, Ealick SE | 2005 Feb 22 | 15709744 |
| RHEA:17509 | H2O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+) |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[n+;H0:3](:[*:4]):[*:5].[OH2;+0:6]>>[*:1]-[CH2;+0:2]-[OH;+0:6].[*:4]:[n;H0;+0:3]:[*:5] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Salvage of the thiamin pyrimidine moiety by plant TenA proteins lacking an active-site cysteine. | Zallot R, Yazdani M, Goyer A, Ziemak MJ, Guan JC, McCarty DR, de Crécy-Lagard V, Gerdes S, Garrett TJ, Benach J, Hunt JF, Shintani DK, Hanson AD | 2014 Oct 1 | 25014715 |
| Structure of trifunctional THI20 from yeast. | French JB, Begley TP, Ealick SE | 2011 Sep | 21904031 |
| Structural and mutational analysis of TenA protein (HP1287) from the Helicobacter pylori thiamin salvage pathway - evidence of a different substrate specificity. | Barison N, Cendron L, Trento A, Angelini A, Zanotti G | 2009 Nov | 19780837 |
| Mutagenesis studies on TenA: a thiamin salvage enzyme from Bacillus subtilis. | Jenkins AL, Zhang Y, Ealick SE, Begley TP | 2008 Feb | 18054064 |
| A new thiamin salvage pathway. | Jenkins AH, Schyns G, Potot S, Sun G, Begley TP | 2007 Aug | 17618314 |
| The 2.35 A structure of the TenA homolog from Pyrococcus furiosus supports an enzymatic function in thiamine metabolism. | Benach J, Edstrom WC, Lee I, Das K, Cooper B, Xiao R, Liu J, Rost B, Acton TB, Montelione GT, Hunt JF | 2005 May | 15858269 |
| Structural characterization of the regulatory proteins TenA and TenI from Bacillus subtilis and identification of TenA as a thiaminase II. | Toms AV, Haas AL, Park JH, Begley TP, Ealick SE | 2005 Feb 22 | 15709744 |