Enzyme

Download
EC Tree
     3. Hydrolases
        3.6 Acting on acid anhydrides
            3.6.1 In phosphorus-containing anhydrides
ID:3.6.1.11
Description:Exopolyphosphatase.
Alternative Name: Metaphosphatase.
Exopolypase.
Cath: 1.10.3210.10; 3.30.420.150; 3.30.420.40; 3.30.70.2260; 3.40.1210.10; 3.90.1640.10; 3.10.310.20;

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.

References

External Links

UniProtKB Enzyme Link: UniProtKB 3.6.1.11
BRENDA Enzyme Link: BRENDA 3.6.1.11
KEGG Enzyme Link: KEGG3.6.1.11
BioCyc Enzyme Link: BioCyc 3.6.1.11
ExPASy Enzyme Link: ExPASy3.6.1.11
EC2PDB Enzyme Link: EC2PDB 3.6.1.11
ExplorEnz Enzyme Link: ExplorEnz 3.6.1.11
PRIAM enzyme-specific profiles Link: PRIAM 3.6.1.11
IntEnz Enzyme Link: IntEnz 3.6.1.11
MEDLINE Enzyme Link: MEDLINE 3.6.1.11
MSA:

3.6.1.11;

Phylogenetic Tree:

3.6.1.11;

Uniprot:
M-CSA:
RHEA:21528 [phosphate](n) + H2O = [phosphate](n-1) + H(+) + phosphate
RULE(radius=1) [*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Pseudomonas aeruginosa Exopolyphosphatase Is Also a Polyphosphate: ADP Phosphotransferase.Beassoni PR, Gallarato LA, Boetsch C, Garrido MN, Lisa AT201526576296
Manipulation of independent synthesis and degradation of polyphosphate in Escherichia coli for investigation of phosphate secretion from the cell.Van Dien SJ, Keyhani S, Yang C, Keasling JD1997 May9143103
An exopolyphosphatase of Escherichia coli. The enzyme and its ppx gene in a polyphosphate operon.Akiyama M, Crooke E, Kornberg A1993 Jan 58380170
Deficiency of the novel exopolyphosphatase Rv1026/PPX2 leads to metabolic downshift and altered cell wall permeability in Mycobacterium tuberculosis.Chuang YM, Bandyopadhyay N, Rifat D, Rubin H, Bader JS, Karakousis PC2015 Mar 1725784702
The role of the novel exopolyphosphatase MT0516 in Mycobacterium tuberculosis drug tolerance and persistence.Thayil SM, Morrison N, Schechter N, Rubin H, Karakousis PC201122132215
Origin of exopolyphosphatase processivity: Fusion of an ASKHA phosphotransferase and a cyclic nucleotide phosphodiesterase homolog.Alvarado J, Ghosh A, Janovitz T, Jauregui A, Hasson MS, Sanders DA2006 Aug16905100
Endopolyphosphatase in Saccharomyces cerevisiae undergoes post-translational activations to produce short-chain polyphosphates.Shi X, Kornberg A2005 Mar 2815792812
The gene for an exopolyphosphatase of Pseudomonas aeruginosa.Miyake T, Shiba T, Kameda A, Ihara Y, Munekata M, Ishige K, Noguchi T1999 Apr 3010382967