EC number:3.6.1.22
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.6 Acting on acid anhydrides |
| 3.6.1 In phosphorus-containing anhydrides |
| ID: | 3.6.1.22 | ||
|---|---|---|---|
| Description: | NAD(+) diphosphatase. | ||
| Alternative Name: |
Nicotinamide adenine dinucleotide pyrophosphatase. NADP pyrophosphatase. NADH pyrophosphatase. | ||
| Prosite: | PDOC00695; | ||
| PDB: |
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| Cath: | 3.90.79.10; 3.90.79.20; 3.40.30.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.6.1.22 |
| BRENDA Enzyme Link: | BRENDA 3.6.1.22 |
| KEGG Enzyme Link: | KEGG3.6.1.22 |
| BioCyc Enzyme Link: | BioCyc 3.6.1.22 |
| ExPASy Enzyme Link: | ExPASy3.6.1.22 |
| EC2PDB Enzyme Link: | EC2PDB 3.6.1.22 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.6.1.22 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.6.1.22 |
| IntEnz Enzyme Link: | IntEnz 3.6.1.22 |
| MEDLINE Enzyme Link: | MEDLINE 3.6.1.22 |
| RHEA:48868 | H2O + NADH = AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide |
| RULE(radius=1) | [*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cloning, purification, and properties of a novel NADH pyrophosphatase. Evidence for a nucleotide pyrophosphatase catalytic domain in MutT-like enzymes. | Frick DN, Bessman MJ | 1995 Jan 27 | 7829480 |
| Nucleotidases in plants. I. Partial purification and properties of the enzyme hydrolyzing flavine adenine dinucleotide from mung bean seedlings (Phaseolus radiatus). | Kumar SA, Rao NA, Vaidyanathan CS | 1965 Sep | 5862212 |
| Purification and properties of NADP pyrophosphatase from Proteus vulgaris. | Nakajima Y, Fukunaga N, Sasaki S, Usami S | 1973 Jan 12 | 4405504 |
| Nicotinamide-adenine dinucleotide pyrophosphatase in the growing and aging mosquito. | Anderson BM, Lang CA | 1966 Nov | 4381708 |
| Analysis of Arabidopsis growth factor gene 1 (GFG1) encoding a nudix hydrolase during oxidative signaling. | Jambunathan N, Mahalingam R | 2006 Jun | 16328543 |
| A heat-activated diphosphopyridine nucleotide pyrophosphatase from Proteus vulgaris. | SWARTZ MN, KAPLAN NO, LAMBORG MF | 1958 Jun | 13549486 |
| A reduced pyridine nucleotide pyrophosphatase. | JACOBSON KB, KAPLAN NO | 1957 May | 13428775 |
| Cloning and characterization of the NADH pyrophosphatases from Caenorhabditis elegans and Saccharomyces cerevisiae, members of a Nudix hydrolase subfamily. | Xu W, Dunn CA, Bessman MJ | 2000 Jul 5 | 10873676 |
| RHEA:11800 | H2O + NAD(+) = AMP + beta-nicotinamide D-ribonucleotide + 2 H(+) |
| RULE(radius=1) | [*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Cloning, purification, and properties of a novel NADH pyrophosphatase. Evidence for a nucleotide pyrophosphatase catalytic domain in MutT-like enzymes. | Frick DN, Bessman MJ | 1995 Jan 27 | 7829480 |
| Nucleotidases in plants. I. Partial purification and properties of the enzyme hydrolyzing flavine adenine dinucleotide from mung bean seedlings (Phaseolus radiatus). | Kumar SA, Rao NA, Vaidyanathan CS | 1965 Sep | 5862212 |
| Purification and properties of NADP pyrophosphatase from Proteus vulgaris. | Nakajima Y, Fukunaga N, Sasaki S, Usami S | 1973 Jan 12 | 4405504 |
| Nicotinamide-adenine dinucleotide pyrophosphatase in the growing and aging mosquito. | Anderson BM, Lang CA | 1966 Nov | 4381708 |
| Analysis of Arabidopsis growth factor gene 1 (GFG1) encoding a nudix hydrolase during oxidative signaling. | Jambunathan N, Mahalingam R | 2006 Jun | 16328543 |
| A heat-activated diphosphopyridine nucleotide pyrophosphatase from Proteus vulgaris. | SWARTZ MN, KAPLAN NO, LAMBORG MF | 1958 Jun | 13549486 |
| A reduced pyridine nucleotide pyrophosphatase. | JACOBSON KB, KAPLAN NO | 1957 May | 13428775 |
| Cloning and characterization of the NADH pyrophosphatases from Caenorhabditis elegans and Saccharomyces cerevisiae, members of a Nudix hydrolase subfamily. | Xu W, Dunn CA, Bessman MJ | 2000 Jul 5 | 10873676 |