EC number:3.6.1.29
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.6 Acting on acid anhydrides |
| 3.6.1 In phosphorus-containing anhydrides |
| ID: | 3.6.1.29 | ||
|---|---|---|---|
| Description: | Bis(5'-adenosyl)-triphosphatase. | ||
| Alternative Name: |
Dinucleosidetriphosphatase. Diadenosine 5',5'''-P(1),P(3)-triphosphate hydrolase. AP3Aase. AP3A hydrolase. AP(3)Aase. AP(3)A hydrolase. | ||
| Prosite: | PDOC00694; | ||
| PDB: |
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| Cath: | 3.30.1360.180; 3.30.428.10; 3.40.720.10; 3.60.110.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.6.1.29 |
| BRENDA Enzyme Link: | BRENDA 3.6.1.29 |
| KEGG Enzyme Link: | KEGG3.6.1.29 |
| BioCyc Enzyme Link: | BioCyc 3.6.1.29 |
| ExPASy Enzyme Link: | ExPASy3.6.1.29 |
| EC2PDB Enzyme Link: | EC2PDB 3.6.1.29 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.6.1.29 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.6.1.29 |
| IntEnz Enzyme Link: | IntEnz 3.6.1.29 |
| MEDLINE Enzyme Link: | MEDLINE 3.6.1.29 |
| RHEA:13893 | H2O + P(1),P(3)-bis(5'-adenosyl) triphosphate = ADP + AMP + 2 H(+) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans. | Pekarsky Y, Campiglio M, Siprashvili Z, Druck T, Sedkov Y, Tillib S, Draganescu A, Wermuth P, Rothman JH, Huebner K, Buchberg AM, Mazo A, Brenner C, Croce CM | 1998 Jul 21 | 9671749 |
| Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit. | Pace HC, Garrison PN, Robinson AK, Barnes LD, Draganescu A, Rösler A, Blackburn GM, Siprashvili Z, Croce CM, Huebner K, Brenner C | 1998 May 12 | 9576908 |
| Structure-based analysis of catalysis and substrate definition in the HIT protein family. | Lima CD, Klein MG, Hendrickson WA | 1997 Oct 10 | 9323207 |
| Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolase. | Barnes LD, Garrison PN, Siprashvili Z, Guranowski A, Robinson AK, Ingram SW, Croce CM, Ohta M, Huebner K | 1996 Sep 10 | 8794732 |
| Molecular basis of purinergic signal metabolism by ectonucleotide pyrophosphatase/phosphodiesterases 4 and 1 and implications in stroke. | Albright RA, Ornstein DL, Cao W, Chang WC, Robert D, Tehan M, Hoyer D, Liu L, Stabach P, Yang G, De La Cruz EM, Braddock DT | 2014 Feb 7 | 24338010 |
| NPP4 is a procoagulant enzyme on the surface of vascular endothelium. | Albright RA, Chang WC, Robert D, Ornstein DL, Cao W, Liu L, Redick ME, Young JI, De La Cruz EM, Braddock DT | 2012 Nov 22 | 22995898 |
| The mechanism of action of the fragile histidine triad, Fhit: isolation of a covalent adenylyl enzyme and chemical rescue of H96G-Fhit. | Huang K, Arabshahi A, Wei Y, Frey PA | 2004 Jun 15 | 15182206 |
| Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding. | Trapasso F, Krakowiak A, Cesari R, Arkles J, Yendamuri S, Ishii H, Vecchione A, Kuroki T, Bieganowski P, Pace HC, Huebner K, Croce CM, Brenner C | 2003 Feb 18 | 12574506 |
| Crystal structure of the worm NitFhit Rosetta Stone protein reveals a Nit tetramer binding two Fhit dimers. | Pace HC, Hodawadekar SC, Draganescu A, Huang J, Bieganowski P, Pekarsky Y, Croce CM, Brenner C | 2000 Jul 27-Aug 10 | 10959838 |