EC number:3.6.1.52
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.6 Acting on acid anhydrides |
| 3.6.1 In phosphorus-containing anhydrides |
| ID: | 3.6.1.52 | ||
|---|---|---|---|
| Description: | Diphosphoinositol-polyphosphate diphosphatase. | ||
| Alternative Name: |
DIPP. Diphosphoinositol-polyphosphate phosphohydrolase. | ||
| Prosite: | PDOC00695; | ||
| PDB: |
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| Cath: | 3.90.79.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.6.1.52 |
| BRENDA Enzyme Link: | BRENDA 3.6.1.52 |
| KEGG Enzyme Link: | KEGG3.6.1.52 |
| BioCyc Enzyme Link: | BioCyc 3.6.1.52 |
| ExPASy Enzyme Link: | ExPASy3.6.1.52 |
| EC2PDB Enzyme Link: | EC2PDB 3.6.1.52 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.6.1.52 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.6.1.52 |
| IntEnz Enzyme Link: | IntEnz 3.6.1.52 |
| MEDLINE Enzyme Link: | MEDLINE 3.6.1.52 |
| RHEA:56312 | 3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + 2 H(+) + phosphate |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase. | Safrany ST, Caffrey JJ, Yang X, Bembenek ME, Moyer MB, Burkhart WA, Shears SB | 1998 Nov 16 | 9822604 |
| RHEA:22384 | 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + H(+) + phosphate |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family. | Caffrey JJ, Safrany ST, Yang X, Shears SB | 2000 Apr 28 | 10777568 |
| A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase. | Safrany ST, Caffrey JJ, Yang X, Bembenek ME, Moyer MB, Burkhart WA, Shears SB | 1998 Nov 16 | 9822604 |