EC number:3.6.1.56

Enzyme

Download
EC Tree
     3. Hydrolases
        3.6 Acting on acid anhydrides
            3.6.1 In phosphorus-containing anhydrides
ID:3.6.1.56
Description:2-hydroxy-dATP diphosphatase.
Alternative Name: Oxidized purine nucleoside triphosphatase.
(2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase.
Cath: 3.90.79.10;

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.
PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 3.6.1.56
BRENDA Enzyme Link: BRENDA 3.6.1.56
KEGG Enzyme Link: KEGG3.6.1.56
BioCyc Enzyme Link: BioCyc 3.6.1.56
ExPASy Enzyme Link: ExPASy3.6.1.56
EC2PDB Enzyme Link: EC2PDB 3.6.1.56
ExplorEnz Enzyme Link: ExplorEnz 3.6.1.56
PRIAM enzyme-specific profiles Link: PRIAM 3.6.1.56
IntEnz Enzyme Link: IntEnz 3.6.1.56
MEDLINE Enzyme Link: MEDLINE 3.6.1.56

EC number:3.6.1.56

MSA:

3.6.1.56;
Phylogenetic Tree:

3.6.1.56;
Uniprot:
M-CSA:
RHEA:31583 2-hydroxy-dATP + H2O = 2-hydroxy-dAMP + diphosphate + H(+)
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1.Sakai Y, Furuichi M, Takahashi M, Mishima M, Iwai S, Shirakawa M, Nakabeppu Y2002 Mar 811756418
Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP.Fujikawa K, Kamiya H, Yakushiji H, Nakabeppu Y, Kasai H2001 Jan 1511139615