EC number:3.6.1.58
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.6 Acting on acid anhydrides |
| 3.6.1 In phosphorus-containing anhydrides |
| ID: | 3.6.1.58 |
|---|---|
| Description: | 8-oxo-dGDP phosphatase. |
| Cath: | 3.90.79.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.6.1.58 |
| BRENDA Enzyme Link: | BRENDA 3.6.1.58 |
| KEGG Enzyme Link: | KEGG3.6.1.58 |
| BioCyc Enzyme Link: | BioCyc 3.6.1.58 |
| ExPASy Enzyme Link: | ExPASy3.6.1.58 |
| EC2PDB Enzyme Link: | EC2PDB 3.6.1.58 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.6.1.58 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.6.1.58 |
| IntEnz Enzyme Link: | IntEnz 3.6.1.58 |
| MEDLINE Enzyme Link: | MEDLINE 3.6.1.58 |
| RHEA:32063 | 8-oxo-dGDP + H2O = 8-oxo-dGMP + H(+) + phosphate |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2. | Takagi Y, Setoyama D, Ito R, Kamiya H, Yamagata Y, Sekiguchi M | 2012 Jun 15 | 22556419 |
| Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein. | Ito R, Sekiguchi M, Setoyama D, Nakatsu Y, Yamagata Y, Hayakawa H | 2011 Jun | 21389046 |
| NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity. | Kamiya H, Hori M, Arimori T, Sekiguchi M, Yamagata Y, Harashima H | 2009 Oct 2 | 19699693 |
| Crystal structures of human NUDT5 reveal insights into the structural basis of the substrate specificity. | Zha M, Zhong C, Peng Y, Hu H, Ding J | 2006 Dec 15 | 17052728 |
| Mammalian enzymes for preventing transcriptional errors caused by oxidative damage. | Ishibashi T, Hayakawa H, Ito R, Miyazawa M, Yamagata Y, Sekiguchi M | 2005 | 16002790 |
| A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides. | Ishibashi T, Hayakawa H, Sekiguchi M | 2003 May | 12717453 |