EC number:3.6.1.59
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.6 Acting on acid anhydrides |
| 3.6.1 In phosphorus-containing anhydrides |
| ID: | 3.6.1.59 |
|---|---|
| Description: | 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase. |
| Alternative Name: |
M(7)GpppX pyrophosphatase. M(7)GpppX diphosphatase. M(7)GpppN m(7)GMP phosphohydrolase. |
| Cath: | 3.30.200.40; 3.30.2240.10; 3.30.428.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.6.1.59 |
| BRENDA Enzyme Link: | BRENDA 3.6.1.59 |
| KEGG Enzyme Link: | KEGG3.6.1.59 |
| BioCyc Enzyme Link: | BioCyc 3.6.1.59 |
| ExPASy Enzyme Link: | ExPASy3.6.1.59 |
| EC2PDB Enzyme Link: | EC2PDB 3.6.1.59 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.6.1.59 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.6.1.59 |
| IntEnz Enzyme Link: | IntEnz 3.6.1.59 |
| MEDLINE Enzyme Link: | MEDLINE 3.6.1.59 |
| RHEA:37103 | a 5'-(N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-[mRNA] + H2O = (N(2),N(2),N(7))-trimethylguanosine 5'-phosphate + a 5'-diphospho-[mRNA] + 2 H(+) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](-[*:4])(=[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]-[P;H0;+0:3](=[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Nematode m7GpppG and m3(2,2,7)GpppG decapping: activities in Ascaris embryos and characterization of C. elegans scavenger DcpS. | Cohen LS, Mikhli C, Friedman C, Jankowska-Anyszka M, Stepinski J, Darzynkiewicz E, Davis RE | 2004 Oct | 15383679 |
| RHEA:37099 | a 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] + H2O = a 5'-diphospho-[mRNA] + 2 H(+) + N(7)-methylguanosine 5'-phosphate |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](-[*:4])(=[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]-[P;H0;+0:3](=[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| 7-methylguanosine diphosphate (m(7)GDP) is not hydrolyzed but strongly bound by decapping scavenger (DcpS) enzymes and potently inhibits their activity. | Wypijewska A, Bojarska E, Lukaszewicz M, Stepinski J, Jemielity J, Davis RE, Darzynkiewicz E | 2012 Oct 9 | 22985415 |
| DcpS as a therapeutic target for spinal muscular atrophy. | Singh J, Salcius M, Liu SW, Staker BL, Mishra R, Thurmond J, Michaud G, Mattoon DR, Printen J, Christensen J, Bjornsson JM, Pollok BA, Kiledjian M, Stewart L, Jarecki J, Gurney ME | 2008 Nov 21 | 18839960 |
| Dcs2, a novel stress-induced modulator of m7GpppX pyrophosphatase activity that locates to P bodies. | Malys N, McCarthy JE | 2006 Oct 20 | 16963086 |
| Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping. | Chen N, Walsh MA, Liu Y, Parker R, Song H | 2005 Apr 8 | 15769464 |
| Nematode m7GpppG and m3(2,2,7)GpppG decapping: activities in Ascaris embryos and characterization of C. elegans scavenger DcpS. | Cohen LS, Mikhli C, Friedman C, Jankowska-Anyszka M, Stepinski J, Darzynkiewicz E, Davis RE | 2004 Oct | 15383679 |
| Functional analysis of mRNA scavenger decapping enzymes. | Liu SW, Jiao X, Liu H, Gu M, Lima CD, Kiledjian M | 2004 Sep | 15273322 |
| DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway. | van Dijk E, Le Hir H, Séraphin B | 2003 Oct 14 | 14523240 |
| Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1. | Kwasnicka DA, Krakowiak A, Thacker C, Brenner C, Vincent SR | 2003 Oct 3 | 12871939 |
| A nuclear protein in Schizosaccharomyces pombe with homology to the human tumour suppressor Fhit has decapping activity. | Salehi Z, Geffers L, Vilela C, Birkenhäger R, Ptushkina M, Berthelot K, Ferro M, Gaskell S, Hagan I, Stapley B, McCarthy JE | 2002 Oct | 12366830 |
| Mechanistic and kinetic analysis of the DcpS scavenger decapping enzyme. | Liu SW, Rajagopal V, Patel SS, Kiledjian M | 2008 Jun 13 | 18441014 |