Enzyme

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EC Tree
     3. Hydrolases
        3.6 Acting on acid anhydrides
            3.6.1 In phosphorus-containing anhydrides
ID:3.6.1.62
Description:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase.
Alternative Name: M(7)GpppN-mRNA hydrolase.
Cath: 3.90.79.10;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 3.6.1.62
BRENDA Enzyme Link: BRENDA 3.6.1.62
KEGG Enzyme Link: KEGG3.6.1.62
BioCyc Enzyme Link: BioCyc 3.6.1.62
ExPASy Enzyme Link: ExPASy3.6.1.62
EC2PDB Enzyme Link: EC2PDB 3.6.1.62
ExplorEnz Enzyme Link: ExplorEnz 3.6.1.62
PRIAM enzyme-specific profiles Link: PRIAM 3.6.1.62
IntEnz Enzyme Link: IntEnz 3.6.1.62
MEDLINE Enzyme Link: MEDLINE 3.6.1.62
MSA:

3.6.1.62;

Phylogenetic Tree:

3.6.1.62;

Uniprot:
M-CSA:
RHEA:37371 a 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] + H2O = a 5'-phospho-[mRNA] + 2 H(+) + N(7)-methylguanosine 5'-diphosphate
RULE(radius=1) [*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[O;H0;+0:5]-[*:6].[OH2;+0:7]>>[*:6]-[OH;+0:5].[*:1]-[P;H0;+0:2](=[*:3])(-[*:4])-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA.Lu G, Zhang J, Li Y, Li Z, Zhang N, Xu X, Wang T, Guan Z, Gao GF, Yan J2011 Jan21337011
Multiple mRNA decapping enzymes in mammalian cells.Song MG, Li Y, Kiledjian M2010 Nov 1221070968
Characterization of the vaccinia virus D10 decapping enzyme provides evidence for a two-metal-ion mechanism.Soulière MF, Perreault JP, Bisaillon M2009 Apr 2819210265
Evolutionary conservation supports ancient origin for Nudt16, a nuclear-localized, RNA-binding, RNA-decapping enzyme.Taylor MJ, Peculis BA2008 Oct18820299
Characterization of a second vaccinia virus mRNA-decapping enzyme conserved in poxviruses.Parrish S, Moss B2007 Dec17881455
Metal determines efficiency and substrate specificity of the nuclear NUDIX decapping proteins X29 and H29K (Nudt16).Peculis BA, Reynolds K, Cleland M2007 Aug 2417567574
Vaccinia virus D10 protein has mRNA decapping activity, providing a mechanism for control of host and viral gene expression.Parrish S, Resch W, Moss B2007 Feb 1317283339
Arabidopsis DCP2, DCP1, and VARICOSE form a decapping complex required for postembryonic development.Xu J, Yang JY, Niu QW, Chua NH2006 Dec17158604
Xenopus U8 snoRNA binding protein is a conserved nuclear decapping enzyme.Ghosh T, Peterson B, Tomasevic N, Peculis BA2004 Mar 2615053875
Analysis of recombinant yeast decapping enzyme.Steiger M, Carr-Schmid A, Schwartz DC, Kiledjian M, Parker R2003 Feb12554866
Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures.van Dijk E, Cougot N, Meyer S, Babajko S, Wahle E, Séraphin B2002 Dec 1612486012