EC number:3.6.1.64
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.6 Acting on acid anhydrides |
| 3.6.1 In phosphorus-containing anhydrides |
| ID: | 3.6.1.64 |
|---|---|
| Description: | Inosine diphosphate phosphatase. |
| Alternative Name: |
(Deoxy)inosine diphosphatase. |
| Cath: | 3.90.79.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.6.1.64 |
| BRENDA Enzyme Link: | BRENDA 3.6.1.64 |
| KEGG Enzyme Link: | KEGG3.6.1.64 |
| BioCyc Enzyme Link: | BioCyc 3.6.1.64 |
| ExPASy Enzyme Link: | ExPASy3.6.1.64 |
| EC2PDB Enzyme Link: | EC2PDB 3.6.1.64 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.6.1.64 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.6.1.64 |
| IntEnz Enzyme Link: | IntEnz 3.6.1.64 |
| MEDLINE Enzyme Link: | MEDLINE 3.6.1.64 |
| RHEA:35211 | dIDP + H2O = dIMP + H(+) + phosphate |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate. | Trésaugues L, Lundbäck T, Welin M, Flodin S, Nyman T, Silvander C, Gräslund S, Nordlund P | 2015 | 26121039 |
| NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest. | Iyama T, Abolhassani N, Tsuchimoto D, Nonaka M, Nakabeppu Y | 2010 Aug | 20385596 |
| Evolutionary conservation supports ancient origin for Nudt16, a nuclear-localized, RNA-binding, RNA-decapping enzyme. | Taylor MJ, Peculis BA | 2008 Oct | 18820299 |
| RHEA:35207 | H2O + IDP = H(+) + IMP + phosphate |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate. | Trésaugues L, Lundbäck T, Welin M, Flodin S, Nyman T, Silvander C, Gräslund S, Nordlund P | 2015 | 26121039 |
| NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest. | Iyama T, Abolhassani N, Tsuchimoto D, Nonaka M, Nakabeppu Y | 2010 Aug | 20385596 |
| Metal determines efficiency and substrate specificity of the nuclear NUDIX decapping proteins X29 and H29K (Nudt16). | Peculis BA, Reynolds K, Cleland M | 2007 Aug 24 | 17567574 |