EC number:3.6.1.65
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.6 Acting on acid anhydrides |
| 3.6.1 In phosphorus-containing anhydrides |
| ID: | 3.6.1.65 |
|---|---|
| Description: | (d)CTP diphosphatase. |
| Alternative Name: |
(d)CTP pyrophosphohydrolase. (d)CTP diphosphohydrolase. |
| Cath: | 3.90.79.10; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 3.6.1.65 |
| BRENDA Enzyme Link: | BRENDA 3.6.1.65 |
| KEGG Enzyme Link: | KEGG3.6.1.65 |
| BioCyc Enzyme Link: | BioCyc 3.6.1.65 |
| ExPASy Enzyme Link: | ExPASy3.6.1.65 |
| EC2PDB Enzyme Link: | EC2PDB 3.6.1.65 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.6.1.65 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.6.1.65 |
| IntEnz Enzyme Link: | IntEnz 3.6.1.65 |
| MEDLINE Enzyme Link: | MEDLINE 3.6.1.65 |
| RHEA:27762 | CTP + H2O = CMP + diphosphate + H(+) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| MazG, a nucleoside triphosphate pyrophosphohydrolase, interacts with Era, an essential GTPase in Escherichia coli. | Zhang J, Inouye M | 2002 Oct | 12218018 |
| Biochemical and structural studies of conserved Maf proteins revealed nucleotide pyrophosphatases with a preference for modified nucleotides. | Tchigvintsev A, Tchigvintsev D, Flick R, Popovic A, Dong A, Xu X, Brown G, Lu W, Wu H, Cui H, Dombrowski L, Joo JC, Beloglazova N, Min J, Savchenko A, Caudy AA, Rabinowitz JD, Murzin AG, Yakunin AF | 2013 Nov 21 | 24210219 |
| Orf135 from Escherichia coli Is a Nudix hydrolase specific for CTP, dCTP, and 5-methyl-dCTP. | O'Handley SF, Dunn CA, Bessman MJ | 2001 Feb 23 | 11053429 |
| RHEA:22636 | dCTP + H2O = dCMP + diphosphate + H(+) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| MazG, a nucleoside triphosphate pyrophosphohydrolase, interacts with Era, an essential GTPase in Escherichia coli. | Zhang J, Inouye M | 2002 Oct | 12218018 |
| Orf135 from Escherichia coli Is a Nudix hydrolase specific for CTP, dCTP, and 5-methyl-dCTP. | O'Handley SF, Dunn CA, Bessman MJ | 2001 Feb 23 | 11053429 |