EC number:3.6.1.66
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.6 Acting on acid anhydrides |
| 3.6.1 In phosphorus-containing anhydrides |
| ID: | 3.6.1.66 |
|---|---|
| Description: | XTP/dITP diphosphatase. |
| Alternative Name: |
Hypoxanthine/xanthine dNTP pyrophosphatase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.6.1.66 |
| BRENDA Enzyme Link: | BRENDA 3.6.1.66 |
| KEGG Enzyme Link: | KEGG3.6.1.66 |
| BioCyc Enzyme Link: | BioCyc 3.6.1.66 |
| ExPASy Enzyme Link: | ExPASy3.6.1.66 |
| EC2PDB Enzyme Link: | EC2PDB 3.6.1.66 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.6.1.66 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.6.1.66 |
| IntEnz Enzyme Link: | IntEnz 3.6.1.66 |
| MEDLINE Enzyme Link: | MEDLINE 3.6.1.66 |
| RHEA:29399 | H2O + ITP = diphosphate + H(+) + IMP |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Molecular basis of the antimutagenic activity of the house-cleaning inosine triphosphate pyrophosphatase RdgB from Escherichia coli. | Savchenko A, Proudfoot M, Skarina T, Singer A, Litvinova O, Sanishvili R, Brown G, Chirgadze N, Yakunin AF | 2007 Dec 7 | 17976651 |
| Identification of the dITP- and XTP-hydrolyzing protein from Escherichia coli. | Chung JH, Park HY, Lee JH, Jang Y | 2002 Jul 31 | 12297000 |
| Biochemical characterization of a novel hypoxanthine/xanthine dNTP pyrophosphatase from Methanococcus jannaschii. | Chung JH, Back JH, Park YI, Han YS | 2001 Jul 15 | 11452035 |
| Structure-based identification of a novel NTPase from Methanococcus jannaschii. | Hwang KY, Chung JH, Kim SH, Han YS, Cho Y | 1999 Jul | 10404228 |
| RHEA:28610 | H2O + XTP = diphosphate + H(+) + XMP |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| MazG, a nucleoside triphosphate pyrophosphohydrolase, interacts with Era, an essential GTPase in Escherichia coli. | Zhang J, Inouye M | 2002 Oct | 12218018 |
| Molecular basis of the antimutagenic activity of the house-cleaning inosine triphosphate pyrophosphatase RdgB from Escherichia coli. | Savchenko A, Proudfoot M, Skarina T, Singer A, Litvinova O, Sanishvili R, Brown G, Chirgadze N, Yakunin AF | 2007 Dec 7 | 17976651 |
| Identification of the dITP- and XTP-hydrolyzing protein from Escherichia coli. | Chung JH, Park HY, Lee JH, Jang Y | 2002 Jul 31 | 12297000 |
| Biochemical characterization of a novel hypoxanthine/xanthine dNTP pyrophosphatase from Methanococcus jannaschii. | Chung JH, Back JH, Park YI, Han YS | 2001 Jul 15 | 11452035 |
| Structure-based identification of a novel NTPase from Methanococcus jannaschii. | Hwang KY, Chung JH, Kim SH, Han YS, Cho Y | 1999 Jul | 10404228 |
| RHEA:28342 | dITP + H2O = dIMP + diphosphate + H(+) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| MazG, a nucleoside triphosphate pyrophosphohydrolase, interacts with Era, an essential GTPase in Escherichia coli. | Zhang J, Inouye M | 2002 Oct | 12218018 |
| Molecular basis of the antimutagenic activity of the house-cleaning inosine triphosphate pyrophosphatase RdgB from Escherichia coli. | Savchenko A, Proudfoot M, Skarina T, Singer A, Litvinova O, Sanishvili R, Brown G, Chirgadze N, Yakunin AF | 2007 Dec 7 | 17976651 |
| Identification of the dITP- and XTP-hydrolyzing protein from Escherichia coli. | Chung JH, Park HY, Lee JH, Jang Y | 2002 Jul 31 | 12297000 |
| Biochemical characterization of a novel hypoxanthine/xanthine dNTP pyrophosphatase from Methanococcus jannaschii. | Chung JH, Back JH, Park YI, Han YS | 2001 Jul 15 | 11452035 |