EC number:3.6.1.67
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.6 Acting on acid anhydrides |
| 3.6.1 In phosphorus-containing anhydrides |
| ID: | 3.6.1.67 |
|---|---|
| Description: | Dihydroneopterin triphosphate diphosphatase. |
| Alternative Name: |
Dihydroneopterin triphosphate pyrophosphohydrolase. |
| Cath: | 3.90.79.10; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 3.6.1.67 |
| BRENDA Enzyme Link: | BRENDA 3.6.1.67 |
| KEGG Enzyme Link: | KEGG3.6.1.67 |
| BioCyc Enzyme Link: | BioCyc 3.6.1.67 |
| ExPASy Enzyme Link: | ExPASy3.6.1.67 |
| EC2PDB Enzyme Link: | EC2PDB 3.6.1.67 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.6.1.67 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.6.1.67 |
| IntEnz Enzyme Link: | IntEnz 3.6.1.67 |
| MEDLINE Enzyme Link: | MEDLINE 3.6.1.67 |
| RHEA:25302 | 7,8-dihydroneopterin 3'-triphosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + diphosphate + H(+) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Escherichia coli orf17 codes for a nucleoside triphosphate pyrophosphohydrolase member of the MutT family of proteins. Cloning, purification, and characterization of the enzyme. | O'Handley SF, Frick DN, Bullions LC, Mildvan AS, Bessman MJ | 1996 Oct 4 | 8798731 |
| The biosynthesis of folic acid. XII. Purification and properties of dihydroneopterin triphosphate pyrophosphohydrolase. | Suzuki Y, Brown GM | 1974 Apr 25 | 4362677 |
| Structure and function of the E. coli dihydroneopterin triphosphate pyrophosphatase: a Nudix enzyme involved in folate biosynthesis. | Gabelli SB, Bianchet MA, Xu W, Dunn CA, Niu ZD, Amzel LM, Bessman MJ | 2007 Aug | 17698004 |
| A nudix enzyme removes pyrophosphate from dihydroneopterin triphosphate in the folate synthesis pathway of bacteria and plants. | Klaus SM, Wegkamp A, Sybesma W, Hugenholtz J, Gregory JF 3rd, Hanson AD | 2005 Feb 18 | 15611104 |