EC number:3.6.1.8
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.6 Acting on acid anhydrides |
| 3.6.1 In phosphorus-containing anhydrides |
| ID: | 3.6.1.8 |
|---|---|
| Description: | ATP diphosphatase. |
| Alternative Name: |
ATPase. ATP pyrophosphatase. |
| Cath: | 1.10.287.10; 1.10.287.1080; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.6.1.8 |
| BRENDA Enzyme Link: | BRENDA 3.6.1.8 |
| KEGG Enzyme Link: | KEGG3.6.1.8 |
| BioCyc Enzyme Link: | BioCyc 3.6.1.8 |
| ExPASy Enzyme Link: | ExPASy3.6.1.8 |
| EC2PDB Enzyme Link: | EC2PDB 3.6.1.8 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.6.1.8 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.6.1.8 |
| IntEnz Enzyme Link: | IntEnz 3.6.1.8 |
| MEDLINE Enzyme Link: | MEDLINE 3.6.1.8 |
| RHEA:14245 | ATP + H2O = AMP + diphosphate + H(+) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](-[*:4])(=[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]-[P;H0;+0:3](=[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| MazG, a nucleoside triphosphate pyrophosphohydrolase, interacts with Era, an essential GTPase in Escherichia coli. | Zhang J, Inouye M | 2002 Oct | 12218018 |
| RHEA:27762 | CTP + H2O = CMP + diphosphate + H(+) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| MazG, a nucleoside triphosphate pyrophosphohydrolase, interacts with Era, an essential GTPase in Escherichia coli. | Zhang J, Inouye M | 2002 Oct | 12218018 |
| Biochemical and structural studies of conserved Maf proteins revealed nucleotide pyrophosphatases with a preference for modified nucleotides. | Tchigvintsev A, Tchigvintsev D, Flick R, Popovic A, Dong A, Xu X, Brown G, Lu W, Wu H, Cui H, Dombrowski L, Joo JC, Beloglazova N, Min J, Savchenko A, Caudy AA, Rabinowitz JD, Murzin AG, Yakunin AF | 2013 Nov 21 | 24210219 |
| Orf135 from Escherichia coli Is a Nudix hydrolase specific for CTP, dCTP, and 5-methyl-dCTP. | O'Handley SF, Dunn CA, Bessman MJ | 2001 Feb 23 | 11053429 |
| RHEA:29391 | GTP + H2O = diphosphate + GMP + H(+) |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| MazG, a nucleoside triphosphate pyrophosphohydrolase, interacts with Era, an essential GTPase in Escherichia coli. | Zhang J, Inouye M | 2002 Oct | 12218018 |
| RHEA:29395 | H2O + UTP = diphosphate + H(+) + UMP |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| MazG, a nucleoside triphosphate pyrophosphohydrolase, interacts with Era, an essential GTPase in Escherichia coli. | Zhang J, Inouye M | 2002 Oct | 12218018 |
| Biochemical and structural studies of conserved Maf proteins revealed nucleotide pyrophosphatases with a preference for modified nucleotides. | Tchigvintsev A, Tchigvintsev D, Flick R, Popovic A, Dong A, Xu X, Brown G, Lu W, Wu H, Cui H, Dombrowski L, Joo JC, Beloglazova N, Min J, Savchenko A, Caudy AA, Rabinowitz JD, Murzin AG, Yakunin AF | 2013 Nov 21 | 24210219 |
| RHEA:29399 | H2O + ITP = diphosphate + H(+) + IMP |
| RULE(radius=1) | [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Molecular basis of the antimutagenic activity of the house-cleaning inosine triphosphate pyrophosphatase RdgB from Escherichia coli. | Savchenko A, Proudfoot M, Skarina T, Singer A, Litvinova O, Sanishvili R, Brown G, Chirgadze N, Yakunin AF | 2007 Dec 7 | 17976651 |
| Identification of the dITP- and XTP-hydrolyzing protein from Escherichia coli. | Chung JH, Park HY, Lee JH, Jang Y | 2002 Jul 31 | 12297000 |
| Biochemical characterization of a novel hypoxanthine/xanthine dNTP pyrophosphatase from Methanococcus jannaschii. | Chung JH, Back JH, Park YI, Han YS | 2001 Jul 15 | 11452035 |
| Structure-based identification of a novel NTPase from Methanococcus jannaschii. | Hwang KY, Chung JH, Kim SH, Han YS, Cho Y | 1999 Jul | 10404228 |