EC number:3.6.1.9

Enzyme

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     3. Hydrolases
        3.6 Acting on acid anhydrides
            3.6.1 In phosphorus-containing anhydrides
ID:3.6.1.9
Description:Nucleotide diphosphatase.
Alternative Name: Nucleotide pyrophosphatase.
Nucleoside-triphosphate diphosphatase.
Dinucleotide nucleotidohydrolase.
Cath: 3.30.1360.110; 3.30.1360.180; 4.10.410.20; 3.40.570.10; 3.40.720.10; 3.90.79.10; 3.90.950.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 3.6.1.9
BRENDA Enzyme Link: BRENDA 3.6.1.9
KEGG Enzyme Link: KEGG3.6.1.9
BioCyc Enzyme Link: BioCyc 3.6.1.9
ExPASy Enzyme Link: ExPASy3.6.1.9
EC2PDB Enzyme Link: EC2PDB 3.6.1.9
ExplorEnz Enzyme Link: ExplorEnz 3.6.1.9
PRIAM enzyme-specific profiles Link: PRIAM 3.6.1.9
IntEnz Enzyme Link: IntEnz 3.6.1.9
MEDLINE Enzyme Link: MEDLINE 3.6.1.9

EC number:3.6.1.9

MSA:

3.6.1.9;
Phylogenetic Tree:

3.6.1.9;
Uniprot:
M-CSA:
RHEA:10248 dUTP + H2O = diphosphate + dUMP + H(+)
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Drosophila deoxyuridine triphosphatase. Purification and characterization.Giroir LE, Deutsch WA1987 Jan 53025197
MazG, a nucleoside triphosphate pyrophosphohydrolase, interacts with Era, an essential GTPase in Escherichia coli.Zhang J, Inouye M2002 Oct12218018
RHEA:14245 ATP + H2O = AMP + diphosphate + H(+)
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](-[*:4])(=[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]-[P;H0;+0:3](=[*:5])(-[*:6])-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
MazG, a nucleoside triphosphate pyrophosphohydrolase, interacts with Era, an essential GTPase in Escherichia coli.Zhang J, Inouye M2002 Oct12218018
RHEA:22636 dCTP + H2O = dCMP + diphosphate + H(+)
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
MazG, a nucleoside triphosphate pyrophosphohydrolase, interacts with Era, an essential GTPase in Escherichia coli.Zhang J, Inouye M2002 Oct12218018
Orf135 from Escherichia coli Is a Nudix hydrolase specific for CTP, dCTP, and 5-methyl-dCTP.O'Handley SF, Dunn CA, Bessman MJ2001 Feb 2311053429
RHEA:23996 a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
MazG, a nucleoside triphosphate pyrophosphohydrolase, interacts with Era, an essential GTPase in Escherichia coli.Zhang J, Inouye M2002 Oct12218018
RHEA:27762 CTP + H2O = CMP + diphosphate + H(+)
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
MazG, a nucleoside triphosphate pyrophosphohydrolase, interacts with Era, an essential GTPase in Escherichia coli.Zhang J, Inouye M2002 Oct12218018
Biochemical and structural studies of conserved Maf proteins revealed nucleotide pyrophosphatases with a preference for modified nucleotides.Tchigvintsev A, Tchigvintsev D, Flick R, Popovic A, Dong A, Xu X, Brown G, Lu W, Wu H, Cui H, Dombrowski L, Joo JC, Beloglazova N, Min J, Savchenko A, Caudy AA, Rabinowitz JD, Murzin AG, Yakunin AF2013 Nov 2124210219
Orf135 from Escherichia coli Is a Nudix hydrolase specific for CTP, dCTP, and 5-methyl-dCTP.O'Handley SF, Dunn CA, Bessman MJ2001 Feb 2311053429
RHEA:28334 dATP + H2O = dAMP + diphosphate + H(+)
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](-[*:4])(=[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]-[P;H0;+0:3](=[*:5])(-[*:6])-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
MazG, a nucleoside triphosphate pyrophosphohydrolase, interacts with Era, an essential GTPase in Escherichia coli.Zhang J, Inouye M2002 Oct12218018
RHEA:28342 dITP + H2O = dIMP + diphosphate + H(+)
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
MazG, a nucleoside triphosphate pyrophosphohydrolase, interacts with Era, an essential GTPase in Escherichia coli.Zhang J, Inouye M2002 Oct12218018
Molecular basis of the antimutagenic activity of the house-cleaning inosine triphosphate pyrophosphatase RdgB from Escherichia coli.Savchenko A, Proudfoot M, Skarina T, Singer A, Litvinova O, Sanishvili R, Brown G, Chirgadze N, Yakunin AF2007 Dec 717976651
Identification of the dITP- and XTP-hydrolyzing protein from Escherichia coli.Chung JH, Park HY, Lee JH, Jang Y2002 Jul 3112297000
Biochemical characterization of a novel hypoxanthine/xanthine dNTP pyrophosphatase from Methanococcus jannaschii.Chung JH, Back JH, Park YI, Han YS2001 Jul 1511452035
RHEA:28362 dGTP + H2O = dGMP + diphosphate + H(+)
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
MazG, a nucleoside triphosphate pyrophosphohydrolase, interacts with Era, an essential GTPase in Escherichia coli.Zhang J, Inouye M2002 Oct12218018
RHEA:28534 dTTP + H2O = diphosphate + dTMP + H(+)
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
MazG, a nucleoside triphosphate pyrophosphohydrolase, interacts with Era, an essential GTPase in Escherichia coli.Zhang J, Inouye M2002 Oct12218018
Biochemical and structural studies of conserved Maf proteins revealed nucleotide pyrophosphatases with a preference for modified nucleotides.Tchigvintsev A, Tchigvintsev D, Flick R, Popovic A, Dong A, Xu X, Brown G, Lu W, Wu H, Cui H, Dombrowski L, Joo JC, Beloglazova N, Min J, Savchenko A, Caudy AA, Rabinowitz JD, Murzin AG, Yakunin AF2013 Nov 2124210219
Purification and properties of a nucleoside triphosphate pyrophosphohydrolase from red cells of the rabbit.Chern CJ, MacDonald AB, Morris AJ1969 Oct 254310599
Three new Nudix hydrolases from Escherichia coli.Xu W, Dunn CA, O'handley SF, Smith DL, Bessman MJ2006 Aug 1116766526
RHEA:28610 H2O + XTP = diphosphate + H(+) + XMP
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
MazG, a nucleoside triphosphate pyrophosphohydrolase, interacts with Era, an essential GTPase in Escherichia coli.Zhang J, Inouye M2002 Oct12218018
Molecular basis of the antimutagenic activity of the house-cleaning inosine triphosphate pyrophosphatase RdgB from Escherichia coli.Savchenko A, Proudfoot M, Skarina T, Singer A, Litvinova O, Sanishvili R, Brown G, Chirgadze N, Yakunin AF2007 Dec 717976651
Identification of the dITP- and XTP-hydrolyzing protein from Escherichia coli.Chung JH, Park HY, Lee JH, Jang Y2002 Jul 3112297000
Biochemical characterization of a novel hypoxanthine/xanthine dNTP pyrophosphatase from Methanococcus jannaschii.Chung JH, Back JH, Park YI, Han YS2001 Jul 1511452035
Structure-based identification of a novel NTPase from Methanococcus jannaschii.Hwang KY, Chung JH, Kim SH, Han YS, Cho Y1999 Jul10404228
RHEA:29391 GTP + H2O = diphosphate + GMP + H(+)
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
MazG, a nucleoside triphosphate pyrophosphohydrolase, interacts with Era, an essential GTPase in Escherichia coli.Zhang J, Inouye M2002 Oct12218018
RHEA:29395 H2O + UTP = diphosphate + H(+) + UMP
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
MazG, a nucleoside triphosphate pyrophosphohydrolase, interacts with Era, an essential GTPase in Escherichia coli.Zhang J, Inouye M2002 Oct12218018
Biochemical and structural studies of conserved Maf proteins revealed nucleotide pyrophosphatases with a preference for modified nucleotides.Tchigvintsev A, Tchigvintsev D, Flick R, Popovic A, Dong A, Xu X, Brown G, Lu W, Wu H, Cui H, Dombrowski L, Joo JC, Beloglazova N, Min J, Savchenko A, Caudy AA, Rabinowitz JD, Murzin AG, Yakunin AF2013 Nov 2124210219
RHEA:29399 H2O + ITP = diphosphate + H(+) + IMP
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Molecular basis of the antimutagenic activity of the house-cleaning inosine triphosphate pyrophosphatase RdgB from Escherichia coli.Savchenko A, Proudfoot M, Skarina T, Singer A, Litvinova O, Sanishvili R, Brown G, Chirgadze N, Yakunin AF2007 Dec 717976651
Identification of the dITP- and XTP-hydrolyzing protein from Escherichia coli.Chung JH, Park HY, Lee JH, Jang Y2002 Jul 3112297000
Biochemical characterization of a novel hypoxanthine/xanthine dNTP pyrophosphatase from Methanococcus jannaschii.Chung JH, Back JH, Park YI, Han YS2001 Jul 1511452035
Structure-based identification of a novel NTPase from Methanococcus jannaschii.Hwang KY, Chung JH, Kim SH, Han YS, Cho Y1999 Jul10404228
RHEA:44644 a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
MazG, a nucleoside triphosphate pyrophosphohydrolase, interacts with Era, an essential GTPase in Escherichia coli.Zhang J, Inouye M2002 Oct12218018