EC number:3.6.5.3

Enzyme

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EC Tree
     3. Hydrolases
        3.6 Acting on acid anhydrides
            3.6.5 Acting on GTP to facilitate cellular and subcellular movement
ID:3.6.5.3
Description:Protein-synthesizing GTPase.
Alternative Name: Peptide-release or termination factor.
Peptide-release factor (RF).
Initiation factor (IF).
Elongation factor (EF).
Prosite: PDOC00970; PDOC00905; PDOC00273;
PDB:
PDBScop
6FF4 8089607; 8089608; 8064956; 8064957; 8044675; 8051848; 8044842; 8051197; 8052534; 8052535; 8024083; 8036462; 8028726; 8041105; 8050374; 8053277; 8028316; 8040695; 8061966; 8061967; 8021550; 8033930;
5Z58 8061966; 8061967; 8089607; 8089608; 8029369; 8041748; 8031615; 8043993; 8028726; 8041105; 8050374; 8053277; 8029370; 8041749; 8029369; 8041748; 8022947; 8035327; 8028316; 8040695; 8023813; 8036193; 8055092; 8055093; 8029372; 8041751; 8029370; 8041749; 8044675; 8051848; 8044842; 8051197; 8052534; 8052535; 8029368; 8041747; 8029372; 8041751; 8084946; 8090834; 8029368; 8041747;
2DCU 8056818; 8056819; 8056820; 8056821; 8056822;
2D74 8056818; 8056819; 8056820; 8056821; 8056822;
4M0L 8056813; 8056814; 8056815; 8056816; 8056817; 8056813; 8056814; 8056815; 8056816; 8056817; 8056813; 8056814; 8056815; 8056816; 8056817; 8056813; 8056814; 8056815; 8056816; 8056817; 8056813; 8056814; 8056815; 8056816; 8056817; 8056813; 8056814; 8056815; 8056816; 8056817;
 » show all
Cath: 3.30.420.80; 3.30.70.240; 3.30.70.870; 2.40.30.10; 3.40.50.10050; 3.40.50.300; 2.40.50.250;

3D structure

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PDB

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6FF4; 5Z58; 2DCU; 2D74; 4M0L; 6H6K; 5DSZ; 3I1F; 2PMD; 3QSY; 3V11; 6I5M; 4RJL; 4RD6; 4RD4; 4RD3; 4RD2; 4RD1; 4RD0; 4RCZ; 4RCY; 4QHY; 4QFM; 4NBS; 4M53; 4M4S; 4M2L; 3SJZ; 3PEN; 2PLF; 2C77; 2P8Z; 2P8X; 2P8W; 4LC0; 4LBZ; 4LBY; 4LBW; 4LBV; 4H9G; 1EXM; 6EZE; 2BVN; 1DG1; 3MMP; 1QZD; 1OB2; 1LS2; 5I4R; 1EFM; 4J0Q; 4IW3; 3WXM; 4CXH; 4CXG; 3VMF; 2B7C; 2B7B; 1IJF; 1G7C; 1HA3; 1ZC8; 2C78; 1D2E; 1TUI; 1TTT; 1OB5; 1MJ1; 1EFT; 1B23; 3MCA; 2HCJ; 4Q7J; 3U6K; 3U6B; 1EFC; 1D8T; 3EQ4; 3EQ3; 3EP2; 4PC3; 5JBQ; 4G5G; 3U2Q; 2FX3; 2HDN; 1ETU; 3J81; 5LJ5; 5JBH; 3JAP; 3JAM; 5ME0; 4D61; 4KZZ; 5ZWO; 3JAQ; 3JB9; 4KZY; 3J80; 5LQW; 2OM7; 3DNY; 3B82; 1ZM3; 1ZM2; 2NPF; 1N0V; 3B78; 1ZM9; 1ZM4; 2P8Y; 2E1R; 1U2R; 1N0U; 1XB2; 3JCM; 6BK8; 5MQ0; 5GAM; 5MQF; 5O9Z; 6O81; 6O85; 6I7T; 6I3M; 1D1N; 1D7Q; 3JCR; 6ID0; 6ICZ; 6ID1; 6AH0; 6FF7; 1KTV; 1JQM; 4MYU; 4MYT; 4M1K; 3IZP; 2J7K; 2BV3; 2BM1; 2BM0; 1PN6; 1FNM; 5MPS; 6J6N; 5Y88; 5WSG; 6J6Q; 6J6G; 5GMK; 6EXN; 6J6H; 3IZQ; 2AHO; 3B8H; 2ZIT; 2QN6; 2QMU; 3CW2; 3J0E; 5O8W; 1IJE; 1F60; 3J5Y; 5ME1; 1JT8; 5GAN; 5JB3; 2RDO; 3DEG; 1ZN0; 4R71; 1EFU; 4PC7; 1AIP; 1G7T; 1G7S; 1G7R; 1KK3; 1KK2; 1KK1; 1KK0; 1KJZ; 3P27; 3P26; 1R5O; 1R5N; 1R5B; 1SKQ; 1JNY; 1S0U; 6NOT; 6N0I; 6JLX; 6JLW; 6BK7; 6B8D; 5YT0; 5YLZ; 5W75; 5VH6; 5TY0; 5TV2; 5LMV; 5LJ3; 5IZM; 5IZL; 5IZK; 5H7L; 5H7K; 5H7J; 5FG3; 5ANC; 5ANB; 5A9Y; 5A9X; 5A9W; 4ZV4; 4ZKE; 4ZKD; 4ZCM; 4ZCL; 4ZCI; 4TN1; 4TMZ; 4TMX; 4TMW; 4TMV; 4TMT; 4NCN; 4NCL; 4NCF; 4N3S; 4N3N; 4MNO; 4KJZ; 4FWT; 4FN5; 4CRN; 4C0S; 4B48; 4B47; 4B44; 4B43; 4B3X; 3ZZU; 3ZZT; 3ZZ0; 3WYA; 3WY9; 3WBK; 3WBJ; 3WBI; 3VR1; 3VQT; 3VNV; 3VNU; 3TR5; 3J4J; 3J25; 3IZY; 3CB4; 3AVY; 3AVX; 3AVW; 3AVV; 3AVU; 3AVT; 3AGQ; 3AGP; 2YWH; 2YWG; 2YWF; 2YWE; 2XEX; 2O0F; 2LKD; 2LKC; 2H5E; 2EFG; 2CRV; 1ZO1; 1ELO; 1EFG; 1DAR;

References

External Links

UniProtKB Enzyme Link: UniProtKB 3.6.5.3
BRENDA Enzyme Link: BRENDA 3.6.5.3
KEGG Enzyme Link: KEGG3.6.5.3
BioCyc Enzyme Link: BioCyc 3.6.5.3
ExPASy Enzyme Link: ExPASy3.6.5.3
EC2PDB Enzyme Link: EC2PDB 3.6.5.3
ExplorEnz Enzyme Link: ExplorEnz 3.6.5.3
PRIAM enzyme-specific profiles Link: PRIAM 3.6.5.3
IntEnz Enzyme Link: IntEnz 3.6.5.3
MEDLINE Enzyme Link: MEDLINE 3.6.5.3

EC number:3.6.5.3

MSA:

3.6.5.3;
Phylogenetic Tree:

3.6.5.3;
Uniprot:
M-CSA:
RHEA:19669 GTP + H2O = GDP + H(+) + phosphate
RULE(radius=1) [*:1]-[O;H0;+0:2]-[P;H0;+0:3](=[*:4])(-[*:5])-[*:6].[OH2;+0:7]>>[*:1]-[OH;+0:2].[*:4]=[P;H0;+0:3](-[*:5])(-[*:6])-[OH;+0:7]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction