EC number:3.7.1.17
| ID: | 3.7.1.17 |
|---|---|
| Description: | hydrolase. |
| Cath: | 3.40.50.1820; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.7.1.17 |
| BRENDA Enzyme Link: | BRENDA 3.7.1.17 |
| KEGG Enzyme Link: | KEGG3.7.1.17 |
| BioCyc Enzyme Link: | BioCyc 3.7.1.17 |
| ExPASy Enzyme Link: | ExPASy3.7.1.17 |
| EC2PDB Enzyme Link: | EC2PDB 3.7.1.17 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.7.1.17 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.7.1.17 |
| IntEnz Enzyme Link: | IntEnz 3.7.1.17 |
| MEDLINE Enzyme Link: | MEDLINE 3.7.1.17 |
| RHEA:32035 | (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O = (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + H(+) |
| RULE(radius=1) | [*:1]=[C;H0;+0:2](-[*:3])-[C;H0;+0:4](-[*:5])=[*:6].[OH2;+0:7]>>[*:5]-[CH;+0:4]=[*:6].[*:1]=[C;H0;+0:2](-[*:3])-[OH;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism. | Lack NA, Yam KC, Lowe ED, Horsman GP, Owen RL, Sim E, Eltis LD | 2010 Jan 1 | 19875455 |
| Structure of HsaD, a steroid-degrading hydrolase, from Mycobacterium tuberculosis. | Lack N, Lowe ED, Liu J, Eltis LD, Noble ME, Sim E, Westwood IM | 2008 Jan 1 | 18097091 |
| Identification of 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid, 4-hydroxy-2-oxohexanoic acid, and 2-hydroxyhexa-2,4-dienoic acid and related enzymes involved in testosterone degradation in Comamonas testosteroni TA441. | Horinouchi M, Hayashi T, Koshino H, Kurita T, Kudo T | 2005 Sep | 16151114 |
| A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages. | Van der Geize R, Yam K, Heuser T, Wilbrink MH, Hara H, Anderton MC, Sim E, Dijkhuizen L, Davies JE, Mohn WW, Eltis LD | 2007 Feb 6 | 17264217 |