EC number:3.7.1.2
| ID: | 3.7.1.2 |
|---|---|
| Description: | Fumarylacetoacetase. |
| Alternative Name: |
Fumarylacetoacetate hydrolase. Beta-diketonase. |
| Cath: | 3.90.850.10; 2.30.30.230; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.7.1.2 |
| BRENDA Enzyme Link: | BRENDA 3.7.1.2 |
| KEGG Enzyme Link: | KEGG3.7.1.2 |
| BioCyc Enzyme Link: | BioCyc 3.7.1.2 |
| ExPASy Enzyme Link: | ExPASy3.7.1.2 |
| EC2PDB Enzyme Link: | EC2PDB 3.7.1.2 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.7.1.2 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.7.1.2 |
| IntEnz Enzyme Link: | IntEnz 3.7.1.2 |
| MEDLINE Enzyme Link: | MEDLINE 3.7.1.2 |
| RHEA:10244 | 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](=[*:3])-[CH2;+0:4]-[*:5].[OH2;+0:6]>>[*:1]-[C;H0;+0:2](=[*:3])-[OH;+0:6].[*:5]-[CH3;+0:4] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Characterization of the human fumarylacetoacetate hydrolase gene and identification of a missense mutation abolishing enzymatic activity. | Labelle Y, Phaneuf D, Leclerc B, Tanguay RM | 1993 Jul | 8364576 |
| Point mutations in the murine fumarylacetoacetate hydrolase gene: Animal models for the human genetic disorder hereditary tyrosinemia type 1. | Aponte JL, Sega GA, Hauser LJ, Dhar MS, Withrow CM, Carpenter DA, Rinchik EM, Culiat CT, Johnson DK | 2001 Jan 16 | 11209059 |
| Mechanistic inferences from the crystal structure of fumarylacetoacetate hydrolase with a bound phosphorus-based inhibitor. | Bateman RL, Bhanumoorthy P, Witte JF, McClard RW, Grompe M, Timm DE | 2001 May 4 | 11154690 |
| Crystal structure and mechanism of a carbon-carbon bond hydrolase. | Timm DE, Mueller HA, Bhanumoorthy P, Harp JM, Bunick GJ | 1999 Sep 15 | 10508789 |