EC number:3.8.1.11

Enzyme

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     3. Hydrolases
        3.8 Acting on halide bonds
            3.8.1 In carbon-halide compounds
ID:3.8.1.11
Description:2-haloacid dehalogenase (configuration-retaining).
Alternative Name: DL-DEXr.
DL-2-haloacid dehalogenase.
2-haloalkanoid acid halidohydrolase.
2-haloalkanoic acid dehalogenase.
Cath: 1.10.150.240; 3.40.50.1000;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 3.8.1.11
BRENDA Enzyme Link: BRENDA 3.8.1.11
KEGG Enzyme Link: KEGG3.8.1.11
BioCyc Enzyme Link: BioCyc 3.8.1.11
ExPASy Enzyme Link: ExPASy3.8.1.11
EC2PDB Enzyme Link: EC2PDB 3.8.1.11
ExplorEnz Enzyme Link: ExplorEnz 3.8.1.11
PRIAM enzyme-specific profiles Link: PRIAM 3.8.1.11
IntEnz Enzyme Link: IntEnz 3.8.1.11
MEDLINE Enzyme Link: MEDLINE 3.8.1.11

EC number:3.8.1.11

MSA:

3.8.1.11;
Phylogenetic Tree:

3.8.1.11;
Uniprot:
M-CSA:
RHEA:16193 an (R)-2-haloacid + H2O = a (2R)-2-hydroxycarboxylate + a halide anion + H(+)
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[*;H0;+0:4].[OH2;+0:5]>>[*-;H0:4].[*:1]-[CH;+0:2](-[*:3])-[OH;+0:5]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Stereospecificity of 2-monochloropropionate dehalogenation by the two dehalogenases of Pseudomonas putida PP3: evidence for two different dehalogenation mechanisms.Weightman AJ, Weightman AL, Slater JH1982 Aug7142958
RHEA:12072 an (S)-2-haloacid + H2O = a (2S)-2-hydroxycarboxylate + a halide anion + H(+)
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[*;H0;+0:4].[OH2;+0:5]>>[*-;H0:4].[*:1]-[CH;+0:2](-[*:3])-[OH;+0:5]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Stereospecificity of 2-monochloropropionate dehalogenation by the two dehalogenases of Pseudomonas putida PP3: evidence for two different dehalogenation mechanisms.Weightman AJ, Weightman AL, Slater JH1982 Aug7142958