EC number:3.9.1.3
Enzyme
Download| EC Tree |
| 3. Hydrolases |
| 3.9 Acting on phosphorus-nitrogen bonds |
| 3.9.1 Acting on phosphorus-nitrogen bonds (only sub-subclass identified to date) |
| ID: | 3.9.1.3 |
|---|---|
| Description: | Phosphohistidine phosphatase. |
| Alternative Name: |
Protein histidine phosphatase. PHP. |
| Cath: | 3.50.20.20; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 3.9.1.3 |
| BRENDA Enzyme Link: | BRENDA 3.9.1.3 |
| KEGG Enzyme Link: | KEGG3.9.1.3 |
| BioCyc Enzyme Link: | BioCyc 3.9.1.3 |
| ExPASy Enzyme Link: | ExPASy3.9.1.3 |
| EC2PDB Enzyme Link: | EC2PDB 3.9.1.3 |
| ExplorEnz Enzyme Link: | ExplorEnz 3.9.1.3 |
| PRIAM enzyme-specific profiles Link: | PRIAM 3.9.1.3 |
| IntEnz Enzyme Link: | IntEnz 3.9.1.3 |
| MEDLINE Enzyme Link: | MEDLINE 3.9.1.3 |
| RHEA:47964 | H2O + N(pros)-phospho-L-histidyl-[protein] = L-histidyl-[protein] + phosphate |
| RULE(radius=1) | [*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[n;H0;+0:5]1:[*:6]:[n;H0;+0:7]:[*:8]:[*:9]:1.[OH2;+0:10]>>[*:6]1:[n;H0;+0:5]:[*:9]:[*:8]:[nH;+0:7]:1.[*:1]=[P;H0;+0:2](-[*:3])(-[*:4])-[OH;+0:10] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Phosphohistidine phosphatase 1 (PHPT1) also dephosphorylates phospholysine of chemically phosphorylated histone H1 and polylysine. | Ek P, Ek B, Zetterqvist Ö | 2015 Mar | 25574816 |
| Chemical phosphorylation of histidine-containing peptides based on the sequence of histone H4 and their dephosphorylation by protein histidine phosphatase. | Attwood PV, Ludwig K, Bergander K, Besant PG, Adina-Zada A, Krieglstein J, Klumpp S | 2010 Jan | 19836471 |
| Expression of protein histidine phosphatase in Escherichia coli, purification, and determination of enzyme activity. | Bäumer N, Mäurer A, Krieglstein J, Klumpp S | 2007 | 17200567 |
| Protein histidine phosphatase: a novel enzyme with potency for neuronal signaling. | Klumpp S, Hermesmeier J, Selke D, Baumeister R, Kellner R, Krieglstein J | 2002 Dec | 12468887 |
| Identification and characterization of a mammalian 14-kDa phosphohistidine phosphatase. | Ek P, Pettersson G, Ek B, Gong F, Li JP, Zetterqvist O | 2002 Oct | 12383260 |
| RHEA:47960 | H2O + N(tele)-phospho-L-histidyl-[protein] = L-histidyl-[protein] + phosphate |
| RULE(radius=1) | [*:1]:[n;H0;+0:2](:[*:3])-[P;H0;+0:4](=[*:5])(-[*:6])-[*:7].[OH2;+0:8]>>[*:1]:[nH;+0:2]:[*:3].[*:5]=[P;H0;+0:4](-[*:6])(-[*:7])-[OH;+0:8] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Phosphohistidine phosphatase 1 (PHPT1) also dephosphorylates phospholysine of chemically phosphorylated histone H1 and polylysine. | Ek P, Ek B, Zetterqvist Ö | 2015 Mar | 25574816 |
| Chemical phosphorylation of histidine-containing peptides based on the sequence of histone H4 and their dephosphorylation by protein histidine phosphatase. | Attwood PV, Ludwig K, Bergander K, Besant PG, Adina-Zada A, Krieglstein J, Klumpp S | 2010 Jan | 19836471 |
| Expression of protein histidine phosphatase in Escherichia coli, purification, and determination of enzyme activity. | Bäumer N, Mäurer A, Krieglstein J, Klumpp S | 2007 | 17200567 |
| Protein histidine phosphatase: a novel enzyme with potency for neuronal signaling. | Klumpp S, Hermesmeier J, Selke D, Baumeister R, Kellner R, Krieglstein J | 2002 Dec | 12468887 |
| Identification and characterization of a mammalian 14-kDa phosphohistidine phosphatase. | Ek P, Pettersson G, Ek B, Gong F, Li JP, Zetterqvist O | 2002 Oct | 12383260 |