EC number:4.1.1.1
| ID: | 4.1.1.1 | ||
|---|---|---|---|
| Description: | Pyruvate decarboxylase. | ||
| Alternative Name: |
Pyruvic decarboxylase. Alpha-ketoacid carboxylase. Alpha-carboxylase. 2-oxo-acid carboxy-lyase. | ||
| Prosite: | PDOC00166; | ||
| PDB: |
|
||
| Cath: | 3.40.50.970; 3.40.50.1220; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 4.1.1.1 |
| BRENDA Enzyme Link: | BRENDA 4.1.1.1 |
| KEGG Enzyme Link: | KEGG4.1.1.1 |
| BioCyc Enzyme Link: | BioCyc 4.1.1.1 |
| ExPASy Enzyme Link: | ExPASy4.1.1.1 |
| EC2PDB Enzyme Link: | EC2PDB 4.1.1.1 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.1.1.1 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.1.1.1 |
| IntEnz Enzyme Link: | IntEnz 4.1.1.1 |
| MEDLINE Enzyme Link: | MEDLINE 4.1.1.1 |
| RHEA:45484 | H(+) + pyruvate = acetaldehyde + CO2 |
| RULE(radius=1) | [*:1]=[C;H0;+0:2](-[OH;+0:3])-[C;H0;+0:4](=[*:5])-[*:6].[H+;H0:7]>>[*:1]=[C;H0;+0:2]=[O;H0;+0:3].[*:5]=[CH;+0:4]-[*:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The influence of steric and electronic parameters on the substrate behavior of -oxo acids to yeast pyruvate decarboxylase. | Lehmann H, Fischer G, Hübner G, Kohnert KD, Schellenberger A | 1973 Jan 3 | 4687392 |
| Isolation and properties of the carboxylase of wheat germ. | SINGER TP, PENSKY J | 1952 May | 12980978 |
| RHEA:11628 | a 2-oxocarboxylate + H(+) = an aldehyde + CO2 |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](=[*:3])-[C;H0;+0:4](=[*:5])-[OH;+0:6].[H+;H0:7]>>[*:1]-[CH;+0:2]=[*:3].[*:5]=[C;H0;+0:4]=[O;H0;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The influence of steric and electronic parameters on the substrate behavior of -oxo acids to yeast pyruvate decarboxylase. | Lehmann H, Fischer G, Hübner G, Kohnert KD, Schellenberger A | 1973 Jan 3 | 4687392 |
| Effects of deletions at the carboxyl terminus of Zymomonas mobilis pyruvate decarboxylase on the kinetic properties and substrate specificity. | Chang AK, Nixon PF, Duggleby RG | 2000 Aug 8 | 10924138 |