EC number:4.1.1.111
| ID: | 4.1.1.111 |
|---|---|
| Description: | Siroheme decarboxylase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.1.1.111 |
| BRENDA Enzyme Link: | BRENDA 4.1.1.111 |
| KEGG Enzyme Link: | KEGG4.1.1.111 |
| BioCyc Enzyme Link: | BioCyc 4.1.1.111 |
| ExPASy Enzyme Link: | ExPASy4.1.1.111 |
| EC2PDB Enzyme Link: | EC2PDB 4.1.1.111 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.1.1.111 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.1.1.111 |
| IntEnz Enzyme Link: | IntEnz 4.1.1.111 |
| MEDLINE Enzyme Link: | MEDLINE 4.1.1.111 |
EC number:4.1.1.111
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:19093 | 2 H(+) + siroheme = 12,18-didecarboxysiroheme + 2 CO2 |
| RULE(radius=1) | [*:1]=[C;H0;+0:2](-[OH;+0:3])-[CH2;+0:4]-[c;H0;+0:5]1:[c;H0;+0:6](-[*:7]):[c;H0;+0:8]2:[n;H0;+0:9]3:[c;H0;+0:10]:1-[*:11]=[*:12]-[N+;H0:13]1=[C;H0;+0:14](-[*:15])-[CH;+0:16]=[C;H0;+0:17](-[*:18])-[N;H0;+0:19]4-[*:20]=[*:21]-[C;H0;+0:22]5=[N+;H0:23](-[C;H0;+0:24](=[CH;+0:25]-2)-[C;H0;+0:26](-[*:27])=[C;H0;+0:28]-5-[CH2;+0:29]-[C;H0;+0:30](=[*:31])-[OH;+0:32])-[*:33]-1-4-3.[H+;H0:34].[H+;H0:35]>>[*:7]-[C;H0;+0:6]1=[C;H0;+0:5](-[CH3;+0:4])-[C;H0;+0:10]2=[N+;H0:9]3-[C;H0;+0:8]-1=[CH;+0:25]-[c;H0;+0:24]1:[c;H0;+0:26](-[*:27]):[c;H0;+0:28](-[CH3;+0:29]):[c;H0;+0:22]4:[n;H0;+0:23]:1-[*:33]-31-[N+;H0:19](=[C;H0;+0:17](-[*:18])-[CH;+0:16]=[C;H0;+0:14](-[*:15])-[N;H0;+0:13]-1-[*:12]=[*:11]-2)-[*:20]=[*:21]-4.[*:1]=[C;H0;+0:2]=[O;H0;+0:3].[*:31]=[C;H0;+0:30]=[O;H0;+0:32] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The structure, function and properties of sirohaem decarboxylase--an enzyme with structural homology to a transcription factor family that is part of the alternative haem biosynthesis pathway. | Palmer DJ, Schroeder S, Lawrence AD, Deery E, Lobo SA, Saraiva LM, McLean KJ, Munro AW, Ferguson SJ, Pickersgill RW, Brown DG, Warren MJ | 2014 Jul | 24865947 |
| The alternative route to heme in the methanogenic archaeon Methanosarcina barkeri. | Kühner M, Haufschildt K, Neumann A, Storbeck S, Streif J, Layer G | 2014 | 24669201 |
| Molecular hijacking of siroheme for the synthesis of heme and d1 heme. | Bali S, Lawrence AD, Lobo SA, Saraiva LM, Golding BT, Palmer DJ, Howard MJ, Ferguson SJ, Warren MJ | 2011 Nov 8 | 21969545 |