EC number:4.1.1.20
| ID: | 4.1.1.20 | ||
|---|---|---|---|
| Description: | Diaminopimelate decarboxylase. | ||
| Alternative Name: |
Meso-2,6-diaminoheptanedioate carboxy-lyase. DAP decarboxylase. | ||
| Prosite: | PDOC00685; | ||
| PDB: |
|
||
| Cath: | 3.20.20.10; 2.40.37.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.1.1.20 |
| BRENDA Enzyme Link: | BRENDA 4.1.1.20 |
| KEGG Enzyme Link: | KEGG4.1.1.20 |
| BioCyc Enzyme Link: | BioCyc 4.1.1.20 |
| ExPASy Enzyme Link: | ExPASy4.1.1.20 |
| EC2PDB Enzyme Link: | EC2PDB 4.1.1.20 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.1.1.20 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.1.1.20 |
| IntEnz Enzyme Link: | IntEnz 4.1.1.20 |
| MEDLINE Enzyme Link: | MEDLINE 4.1.1.20 |
| RHEA:15101 | H(+) + meso-2,6-diaminopimelate = CO2 + L-lysine |
| RULE(radius=1) | [*:1]=[C;H0;+0:2](-[OH;+0:3])-[CH;+0:4](-[*:5])-[*:6].[H+;H0:7]>>[*:5]-[CH2;+0:4]-[*:6].[*:1]=[C;H0;+0:2]=[O;H0;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Evolution of substrate specificity within a diverse family of beta/alpha-barrel-fold basic amino acid decarboxylases: X-ray structure determination of enzymes with specificity for L-arginine and carboxynorspermidine. | Deng X, Lee J, Michael AJ, Tomchick DR, Goldsmith EJ, Phillips MA | 2010 Aug 13 | 20534592 |
| The catalytic intermediate stabilized by a "down" active site loop for diaminopimelate decarboxylase from Helicobacter pylori. Enzymatic characterization with crystal structure analysis. | Hu T, Wu D, Chen J, Ding J, Jiang H, Shen X | 2008 Jul 25 | 18508763 |
| Diaminopimelic acid decarboxylase in pyridoxin-deficient Escherichia coli. | DENMAN RF, HOARE DS, WORK E | 1955 Mar | 14378182 |
| PURIFICATION AND PROPERTIES OF DIAMINOPIMELATE DECARBOXYLASE FROM ESCHERICHIA COLI. | WHITE PJ, KELLY B | 1965 Jul | 14343156 |
| Cocrystal structures of diaminopimelate decarboxylase: mechanism, evolution, and inhibition of an antibiotic resistance accessory factor. | Ray SS, Bonanno JB, Rajashankar KR, Pinho MG, He G, De Lencastre H, Tomasz A, Burley SK | 2002 Nov | 12429091 |
| Crystallization of diaminopimelate decarboxylase from Escherichia coli, a stereospecific D-amino-acid decarboxylase. | Momany C, Levdikov V, Blagova L, Crews K | 2002 Mar | 11856852 |