EC number:4.1.1.21
| ID: | 4.1.1.21 | ||
|---|---|---|---|
| Description: | Phosphoribosylaminoimidazole carboxylase. | ||
| Alternative Name: |
AIR carboxylase. 5-phosphoribosyl-5-aminoimidazole carboxylase. 5-amino-1-ribosylimidazole 5-phosphate carboxylase. 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase. 1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase. | ||
| Prosite: | PDOC50975; | ||
| PDB: |
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| Cath: | 3.30.1490.20; 3.30.470.20; 3.40.50.7700; 3.40.50.20; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.1.1.21 |
| BRENDA Enzyme Link: | BRENDA 4.1.1.21 |
| KEGG Enzyme Link: | KEGG4.1.1.21 |
| BioCyc Enzyme Link: | BioCyc 4.1.1.21 |
| ExPASy Enzyme Link: | ExPASy4.1.1.21 |
| EC2PDB Enzyme Link: | EC2PDB 4.1.1.21 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.1.1.21 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.1.1.21 |
| IntEnz Enzyme Link: | IntEnz 4.1.1.21 |
| MEDLINE Enzyme Link: | MEDLINE 4.1.1.21 |
| RHEA:10792 | 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2 |
| RULE(radius=1) | [*:1]=[C;H0;+0:2](-[OH;+0:3])-[c;H0;+0:4](:[*:5]):[*:6].[H+;H0:7]>>[*:5]:[cH;+0:4]:[*:6].[*:1]=[C;H0;+0:2]=[O;H0;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Treponema denticola PurE Is a bacterial AIR carboxylase. | Tranchimand S, Starks CM, Mathews II, Hockings SC, Kappock TJ | 2011 May 31 | 21548610 |
| Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis. | Firestine SM, Misialek S, Toffaletti DL, Klem TJ, Perfect JR, Davisson VJ | 1998 Mar 1 | 9500840 |
| Reactions catalyzed by 5-aminoimidazole ribonucleotide carboxylases from Escherichia coli and Gallus gallus: a case for divergent catalytic mechanisms. | Firestine SM, Poon SW, Mueller EJ, Stubbe J, Davisson VJ | 1994 Oct 4 | 7918411 |
| Octameric structure of the human bifunctional enzyme PAICS in purine biosynthesis. | Li SX, Tong YP, Xie XC, Wang QH, Zhou HN, Han Y, Zhang ZY, Gao W, Li SG, Zhang XC, Bi RC | 2007 Mar 9 | 17224163 |