EC number:4.1.1.23

Enzyme

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     4. Lyases
        4.1 Carbon-carbon lyases
            4.1.1 Carboxy-lyases
ID:4.1.1.23
Description:Orotidine-5'-phosphate decarboxylase.
Alternative Name: Uridine 5'-monophosphate synthase.
UMP synthase.
Orotidylic decarboxylase.
Orotidine-5'-phosphate carboxy-lyase.
OMPdcase.
OMP decarboxylase.
Prosite: PDOC00141;
PDB:
PDBScop
3GDK 8030872; 8043251; 8030872; 8043251; 8030872; 8043251; 8030872; 8043251;
1DQX 8030872; 8043251; 8030872; 8043251; 8030872; 8043251; 8030872; 8043251;
1DQW 8030872; 8043251; 8030872; 8043251; 8030872; 8043251; 8030872; 8043251;
3GDL 8030872; 8043251; 8030872; 8043251;
1JJK 8030864; 8043243; 8030864; 8043243; 8030864; 8043243; 8030864; 8043243; 8030864; 8043243; 8030864; 8043243; 8030864; 8043243; 8030864; 8043243; 8030864; 8043243; 8030864; 8043243; 8030864; 8043243; 8030864; 8043243; 8030864; 8043243; 8030864; 8043243; 8030864; 8043243; 8030864; 8043243;
 » show all
Cath: 3.20.20.70; 3.40.50.20; 3.40.50.2020;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 4.1.1.23
BRENDA Enzyme Link: BRENDA 4.1.1.23
KEGG Enzyme Link: KEGG4.1.1.23
BioCyc Enzyme Link: BioCyc 4.1.1.23
ExPASy Enzyme Link: ExPASy4.1.1.23
EC2PDB Enzyme Link: EC2PDB 4.1.1.23
ExplorEnz Enzyme Link: ExplorEnz 4.1.1.23
PRIAM enzyme-specific profiles Link: PRIAM 4.1.1.23
IntEnz Enzyme Link: IntEnz 4.1.1.23
MEDLINE Enzyme Link: MEDLINE 4.1.1.23

EC number:4.1.1.23

MSA:

4.1.1.23;
Phylogenetic Tree:

4.1.1.23;
Uniprot:
M-CSA:
RHEA:11596 H(+) + orotidine 5'-phosphate = CO2 + UMP
RULE(radius=1) [*:1]:[c;H0;+0:2](:[*:3])-[C;H0;+0:4](=[*:5])-[OH;+0:6].[H+;H0:7]>>[*:1]:[cH;+0:2]:[*:3].[*:5]=[C;H0;+0:4]=[O;H0;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Orotidine 5'-Monophosphate Decarboxylase: Probing the Limits of the Possible for Enzyme Catalysis.Richard JP, Amyes TL, Reyes AC2018 Apr 1729595949
Functional analysis of pyrimidine biosynthesis enzymes using the anticancer drug 5-fluorouracil in Caenorhabditis elegans.Kim S, Park DH, Kim TH, Hwang M, Shim J2009 Sep19645718
Rate and Equilibrium Constants for an Enzyme Conformational Change during Catalysis by Orotidine 5'-Monophosphate Decarboxylase.Goryanova B, Goldman LM, Ming S, Amyes TL, Gerlt JA, Richard JP2015 Jul 2826135041