EC number:4.1.1.28
| ID: | 4.1.1.28 | ||
|---|---|---|---|
| Description: | Aromatic-L-amino-acid decarboxylase. | ||
| Alternative Name: |
Tryptophan decarboxylase. L-DOPA decarboxylase. Hydroxytryptophan decarboxylase. DOPA decarboxylase. Aromatic amino acid decarboxylase. 5-hydroxytryptophan decarboxylase. | ||
| Prosite: | PDOC00329; | ||
| PDB: |
|
||
| Cath: | 1.20.1340.10; 3.40.640.10; 3.90.1150.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.1.1.28 |
| BRENDA Enzyme Link: | BRENDA 4.1.1.28 |
| KEGG Enzyme Link: | KEGG4.1.1.28 |
| BioCyc Enzyme Link: | BioCyc 4.1.1.28 |
| ExPASy Enzyme Link: | ExPASy4.1.1.28 |
| EC2PDB Enzyme Link: | EC2PDB 4.1.1.28 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.1.1.28 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.1.1.28 |
| IntEnz Enzyme Link: | IntEnz 4.1.1.28 |
| MEDLINE Enzyme Link: | MEDLINE 4.1.1.28 |
| RHEA:30339 | H(+) + L-tryptophan = CO2 + tryptamine |
| RULE(radius=1) | [*:1]=[C;H0;+0:2](-[OH;+0:3])-[CH;+0:4](-[*:5])-[*:6].[H+;H0:7]>>[*:5]-[CH2;+0:4]-[*:6].[*:1]=[C;H0;+0:2]=[O;H0;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Enzymatic Synthesis of Psilocybin. | Fricke J, Blei F, Hoffmeister D | 2017 Sep 25 | 28763571 |
| Tryptophan decarboxylase is encoded by two autonomously regulated genes in Camptotheca acuminata which are differentially expressed during development and stress. | López-Meyer M, Nessler CL | 1997 Jun | 9225462 |
| Constitutive aromatic L-amino acid decarboxylase from Micrococcus percitreus. | Nakazawa H, Kumagai H, Yamada H | 1974 Nov 6 | 4441405 |
| Partial purification and some properties of tryptophan decarboxylase from a Bacillus strain. | Büki KG, Vinh DQ, Horváth I | 1985 | 4036551 |
| Tryptophan decarboxylase from Catharanthus roseus cell suspension cultures: purification, molecular and kinetic data of the homogenous protein. | Noé W, Mollenschott C, Berlin J | 1984 Sep | 24310513 |
| RHEA:18533 | 5-hydroxy-L-tryptophan + H(+) = CO2 + serotonin |
| RULE(radius=1) | [*:1]=[C;H0;+0:2](-[OH;+0:3])-[CH;+0:4](-[*:5])-[*:6].[H+;H0:7]>>[*:5]-[CH2;+0:4]-[*:6].[*:1]=[C;H0;+0:2]=[O;H0;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Molecular cloning of genomic DNA and chromosomal assignment of the gene for human aromatic L-amino acid decarboxylase, the enzyme for catecholamine and serotonin biosynthesis. | Sumi-Ichinose C, Ichinose H, Takahashi E, Hori T, Nagatsu T | 1992 Mar 3 | 1540578 |
| RHEA:12272 | H(+) + L-dopa = CO2 + dopamine |
| RULE(radius=1) | [*:1]=[C;H0;+0:2](-[OH;+0:3])-[CH;+0:4](-[*:5])-[*:6].[H+;H0:7]>>[*:5]-[CH2;+0:4]-[*:6].[*:1]=[C;H0;+0:2]=[O;H0;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Reactions of DOPA (3,4-dihydroxyphenylalanine) decarboxylase with DOPA. | Minelli A, Charteris AT, Voltattorni CB, John RA | 1979 Nov 1 | 534502 |
| Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases. | Giardina G, Montioli R, Gianni S, Cellini B, Paiardini A, Voltattorni CB, Cutruzzolà F | 2011 Dec 20 | 22143761 |
| Molecular cloning of genomic DNA and chromosomal assignment of the gene for human aromatic L-amino acid decarboxylase, the enzyme for catecholamine and serotonin biosynthesis. | Sumi-Ichinose C, Ichinose H, Takahashi E, Hori T, Nagatsu T | 1992 Mar 3 | 1540578 |
| Dopa decarboxylase (Ddc) affects variation in Drosophila longevity. | De Luca M, Roshina NV, Geiger-Thornsberry GL, Lyman RF, Pasyukova EG, Mackay TF | 2003 Aug | 12881721 |
| Structural insight into Parkinson's disease treatment from drug-inhibited DOPA decarboxylase. | Burkhard P, Dominici P, Borri-Voltattorni C, Jansonius JN, Malashkevich VN | 2001 Nov | 11685243 |