EC number:4.1.1.33

Enzyme

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     4. Lyases
        4.1 Carbon-carbon lyases
            4.1.1 Carboxy-lyases
ID:4.1.1.33
Description:Diphosphomevalonate decarboxylase.
Alternative Name: Mevalonate pyrophosphate decarboxylase.
Mevalonate diphosphate decarboxylase.
Cath: 3.30.230.10; 3.30.70.890;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 4.1.1.33
BRENDA Enzyme Link: BRENDA 4.1.1.33
KEGG Enzyme Link: KEGG4.1.1.33
BioCyc Enzyme Link: BioCyc 4.1.1.33
ExPASy Enzyme Link: ExPASy4.1.1.33
EC2PDB Enzyme Link: EC2PDB 4.1.1.33
ExplorEnz Enzyme Link: ExplorEnz 4.1.1.33
PRIAM enzyme-specific profiles Link: PRIAM 4.1.1.33
IntEnz Enzyme Link: IntEnz 4.1.1.33
MEDLINE Enzyme Link: MEDLINE 4.1.1.33

EC number:4.1.1.33

MSA:

4.1.1.33;
Phylogenetic Tree:

4.1.1.33;
Uniprot:
M-CSA:
RHEA:23732 (R)-5-diphosphomevalonate + ATP = ADP + CO2 + isopentenyl diphosphate + phosphate
RULE(radius=1) [*:1]=[C;H0;+0:2](-[OH;+0:3])-[CH2;+0:4]-[C;H0;+0:5](-[*:6])(-[*:7])-[OH;+0:8].[*:9]=[P;H0;+0:10](-[*:11])(-[*:12])-[O;H0;+0:13]-[*:14]>>[*:6]-[C;H0;+0:5](-[*:7])=[CH2;+0:4].[*:14]-[OH;+0:13].[*:1]=[C;H0;+0:2]=[O;H0;+0:3].[*:9]=[P;H0;+0:10](-[*:11])(-[*:12])-[OH;+0:8]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways.Hinson DD, Chambliss KL, Toth MJ, Tanaka RD, Gibson KM1997 Nov9392419
Biochemical evidence supporting the presence of the classical mevalonate pathway in the thermoacidophilic archaeon Sulfolobus solfataricus.Nishimura H, Azami Y, Miyagawa M, Hashimoto C, Yoshimura T, Hemmi H2013 May23378249
Molecular cloning and expression of the cDNAs encoding human and yeast mevalonate pyrophosphate decarboxylase.Toth MJ, Huwyler L1996 Apr 58626466
Mevalonate-5-diphosphate decarboxylase: stereochemical course of ATP-dependent phosphorylation of mevalonate 5-diphosphate.Iyengar R, Cardemil E, Frey PA1986 Aug 123768305
Substrate binding order in mevalonate 5-diphosphate decarboxylase from chicken liver.Jabalquinto AM, Cardemil E1989 Jul 62752048