EC number:4.1.1.47
| ID: | 4.1.1.47 |
|---|---|
| Description: | Tartronate-semialdehyde synthase. |
| Alternative Name: |
Tartronate semialdehyde carboxylase. Glyoxylate carboligase. |
| Cath: | 3.40.50.970; 3.40.50.1220; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.1.1.47 |
| BRENDA Enzyme Link: | BRENDA 4.1.1.47 |
| KEGG Enzyme Link: | KEGG4.1.1.47 |
| BioCyc Enzyme Link: | BioCyc 4.1.1.47 |
| ExPASy Enzyme Link: | ExPASy4.1.1.47 |
| EC2PDB Enzyme Link: | EC2PDB 4.1.1.47 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.1.1.47 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.1.1.47 |
| IntEnz Enzyme Link: | IntEnz 4.1.1.47 |
| MEDLINE Enzyme Link: | MEDLINE 4.1.1.47 |
| RHEA:10136 | 2 glyoxylate + H(+) = 2-hydroxy-3-oxopropanoate + CO2 |
| RULE(radius=1) | [*:1]-[CH;+0:2]=[O;H0;+0:3].[*:4]=[CH;+0:5]-[C;H0;+0:6](=[*:7])-[OH;+0:8].[H+;H0:9]>>[*:7]=[C;H0;+0:6]=[O;H0;+0:8].[*:4]=[CH;+0:5]-[CH;+0:2](-[*:1])-[OH;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Reaction mechanisms of thiamin diphosphate enzymes: new insights into the role of a conserved glutamate residue. | Shaanan B, Chipman DM | 2009 May | 19476486 |
| Glyoxylate carboligase lacks the canonical active site glutamate of thiamine-dependent enzymes. | Kaplun A, Binshtein E, Vyazmensky M, Steinmetz A, Barak Z, Chipman DM, Tittmann K, Shaanan B | 2008 Feb | 18176558 |
| Evidence for dramatic acceleration of a C-H bond ionization rate in thiamin diphosphate enzymes by the protein environment. | Zhang S, Zhou L, Nemeria N, Yan Y, Zhang Z, Zou Y, Jordan F | 2005 Feb 22 | 15709735 |
| C2-alpha-lactylthiamin diphosphate is an intermediate on the pathway of thiamin diphosphate-dependent pyruvate decarboxylation. Evidence on enzymes and models. | Zhang S, Liu M, Yan Y, Zhang Z, Jordan F | 2004 Dec 24 | 15501823 |
| GLYOXYLATE CARBOLIGASE OF ESCHERICHIA COLI: A FLAVOPROTEIN. | GUPTA NK, VENNESLAND B | 1964 Nov | 14257608 |
| Conversion of glyoxylate to hydroxypyruvate by extracts of Escherichia coli. | BARKULIS SS, KRAKOW G | 1956 Sep | 13363977 |