EC number:4.1.1.49

Enzyme

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     4. Lyases
        4.1 Carbon-carbon lyases
            4.1.1 Carboxy-lyases
ID:4.1.1.49
Description:Phosphoenolpyruvate carboxykinase (ATP).
Alternative Name: Phosphopyruvate carboxylase.
Phosphoenolpyruvate carboxylase.
Phosphoenolpyruvate carboxykinase.
PEPCK.
PEP carboxykinase.
Prosite: PDOC00460;
PDB:
PDBScop
1YVY 8056000; 8056001; 8056002; 8056000; 8056001; 8056002;
1YLH 8055997; 8055998; 8055999;
1YGG 8055997; 8055998; 8055999;
2PC9 8055994; 8055995; 8055996; 8055994; 8055995; 8055996; 8055994; 8055995; 8055996; 8055994; 8055995; 8055996;
1XKV 8055994; 8055995; 8055996; 8055994; 8055995; 8055996;
 » show all
Cath: 3.90.228.20; 2.170.8.10; 3.40.449.10;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 4.1.1.49
BRENDA Enzyme Link: BRENDA 4.1.1.49
KEGG Enzyme Link: KEGG4.1.1.49
BioCyc Enzyme Link: BioCyc 4.1.1.49
ExPASy Enzyme Link: ExPASy4.1.1.49
EC2PDB Enzyme Link: EC2PDB 4.1.1.49
ExplorEnz Enzyme Link: ExplorEnz 4.1.1.49
PRIAM enzyme-specific profiles Link: PRIAM 4.1.1.49
IntEnz Enzyme Link: IntEnz 4.1.1.49
MEDLINE Enzyme Link: MEDLINE 4.1.1.49

EC number:4.1.1.49

MSA:

4.1.1.49;
Phylogenetic Tree:

4.1.1.49;
Uniprot:
M-CSA:
RHEA:18617 ATP + oxaloacetate = ADP + CO2 + phosphoenolpyruvate
RULE(radius=1) [*:1]-[C;H0;+0:2](=[O;H0;+0:3])-[CH2;+0:4]-[C;H0;+0:5](=[*:6])-[OH;+0:7].[*:8]=[P;H0;+0:9](-[*:10])(-[*:11])-[O;H0;+0:12]-[*:13]>>[*:13]-[OH;+0:12].[*:6]=[C;H0;+0:5]=[O;H0;+0:7].[*:8]=[P;H0;+0:9](-[*:10])(-[*:11])-[O;H0;+0:3]-[C;H0;+0:2](-[*:1])=[CH2;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Cloning, sequencing, and overexpression of the Anaerobiospirillum succiniciproducens phosphoenolpyruvate carboxykinase (pckA) gene.Laivenieks M, Vieille C, Zeikus JG1997 Jun9172347
Structure and mechanism of phosphoenolpyruvate carboxykinase.Matte A, Tari LW, Goldie H, Delbaere LT1997 Mar 289139042
Allosteric control by calcium and mechanism of desensitization of phosphoenolpyruvate carboxykinase of Escherichia coli.Goldie AH, Sanwal BD1980 Feb 256986370