EC number:4.1.1.64
| ID: | 4.1.1.64 | ||
|---|---|---|---|
| Description: | 2,2-dialkylglycine decarboxylase (pyruvate). | ||
| Alternative Name: |
L-alanine-alpha-ketobutyrate aminotransferase. | ||
| Prosite: | PDOC00519; | ||
| PDB: |
|
||
| Cath: | 3.40.640.10; 3.90.1150.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.1.1.64 |
| BRENDA Enzyme Link: | BRENDA 4.1.1.64 |
| KEGG Enzyme Link: | KEGG4.1.1.64 |
| BioCyc Enzyme Link: | BioCyc 4.1.1.64 |
| ExPASy Enzyme Link: | ExPASy4.1.1.64 |
| EC2PDB Enzyme Link: | EC2PDB 4.1.1.64 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.1.1.64 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.1.1.64 |
| IntEnz Enzyme Link: | IntEnz 4.1.1.64 |
| MEDLINE Enzyme Link: | MEDLINE 4.1.1.64 |
| RHEA:16073 | 2,2-dialkylglycine + H(+) + pyruvate = CO2 + dialkyl ketone + L-alanine |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3])(-[NH2;+0:4])-[C;H0;+0:5](=[*:6])-[OH;+0:7].[*:8]-[C;H0;+0:9](-[*:10])=[O;H0;+0:11].[H+;H0:12]>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:11].[*:8]-[CH;+0:9](-[*:10])-[NH2;+0:4].[*:6]=[C;H0;+0:5]=[O;H0;+0:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural and mechanistic analysis of two refined crystal structures of the pyridoxal phosphate-dependent enzyme dialkylglycine decarboxylase. | Toney MD, Hohenester E, Keller JW, Jansonius JN | 1995 Jan 13 | 7799433 |
| Directed evolution of the substrate specificity of dialkylglycine decarboxylase. | Taylor JL, Price JE, Toney MD | 2015 Feb | 25500286 |