EC number:4.1.1.72
| ID: | 4.1.1.72 |
|---|---|
| Description: | Branched-chain-2-oxoacid decarboxylase. |
| Alternative Name: |
(3S)-3-methyl-2-oxopentanoate carboxy-lyase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.1.1.72 |
| BRENDA Enzyme Link: | BRENDA 4.1.1.72 |
| KEGG Enzyme Link: | KEGG4.1.1.72 |
| BioCyc Enzyme Link: | BioCyc 4.1.1.72 |
| ExPASy Enzyme Link: | ExPASy4.1.1.72 |
| EC2PDB Enzyme Link: | EC2PDB 4.1.1.72 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.1.1.72 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.1.1.72 |
| IntEnz Enzyme Link: | IntEnz 4.1.1.72 |
| MEDLINE Enzyme Link: | MEDLINE 4.1.1.72 |
| RHEA:54360 | 4-methyl-2-oxopentanoate + H(+) = 3-methylbutanal + CO2 |
| RULE(radius=1) | [*:1]=[C;H0;+0:2](-[OH;+0:3])-[C;H0;+0:4](=[*:5])-[*:6].[H+;H0:7]>>[*:1]=[C;H0;+0:2]=[O;H0;+0:3].[*:5]=[CH;+0:4]-[*:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| An investigation of the metabolism of valine to isobutyl alcohol in Saccharomyces cerevisiae. | Dickinson JR, Harrison SJ, Hewlins MJ | 1998 Oct 2 | 9748245 |
| RHEA:54356 | 3-methyl-2-oxobutanoate + H(+) = 2-methylpropanal + CO2 |
| RULE(radius=1) | [*:1]=[C;H0;+0:2](-[OH;+0:3])-[C;H0;+0:4](=[*:5])-[*:6].[H+;H0:7]>>[*:1]=[C;H0;+0:2]=[O;H0;+0:3].[*:5]=[CH;+0:4]-[*:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| An investigation of the metabolism of valine to isobutyl alcohol in Saccharomyces cerevisiae. | Dickinson JR, Harrison SJ, Hewlins MJ | 1998 Oct 2 | 9748245 |
| RHEA:21108 | (S)-3-methyl-2-oxopentanoate + H(+) = 2-methylbutanal + CO2 |
| RULE(radius=1) | [*:1]=[C;H0;+0:2](-[OH;+0:3])-[C;H0;+0:4](=[*:5])-[*:6].[H+;H0:7]>>[*:1]=[C;H0;+0:2]=[O;H0;+0:3].[*:5]=[CH;+0:4]-[*:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Biosynthesis of branched-chain fatty acids in Bacillus subtilis. A decarboxylase is essential for branched-chain fatty acid synthetase. | Oku H, Kaneda T | 1988 Dec 5 | 3142877 |
| An investigation of the metabolism of isoleucine to active Amyl alcohol in Saccharomyces cerevisiae. | Dickinson JR, Harrison SJ, Dickinson JA, Hewlins MJ | 2000 Apr 14 | 10753893 |