Enzyme

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EC Tree
     4. Lyases
        4.1 Carbon-carbon lyases
            4.1.1 Carboxy-lyases
ID:4.1.1.9
Description:Malonyl-CoA decarboxylase.
Alternative Name: Malonyl-CoA carboxy-lyase.
Cath: 1.20.140.90; 3.40.630.150; 3.40.630.180;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 4.1.1.9
BRENDA Enzyme Link: BRENDA 4.1.1.9
KEGG Enzyme Link: KEGG4.1.1.9
BioCyc Enzyme Link: BioCyc 4.1.1.9
ExPASy Enzyme Link: ExPASy4.1.1.9
EC2PDB Enzyme Link: EC2PDB 4.1.1.9
ExplorEnz Enzyme Link: ExplorEnz 4.1.1.9
PRIAM enzyme-specific profiles Link: PRIAM 4.1.1.9
IntEnz Enzyme Link: IntEnz 4.1.1.9
MEDLINE Enzyme Link: MEDLINE 4.1.1.9
MSA:

4.1.1.9;

Phylogenetic Tree:

4.1.1.9;

Uniprot:
M-CSA:
RHEA:18781 H(+) + malonyl-CoA = acetyl-CoA + CO2
RULE(radius=1) [*:1]=[C;H0;+0:2](-[OH;+0:3])-[CH2;+0:4]-[*:5].[H+;H0:6]>>[*:5]-[CH3;+0:4].[*:1]=[C;H0;+0:2]=[O;H0;+0:3]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Cloning and mutational analysis of human malonyl-coenzyme A decarboxylase.Gao J, Waber L, Bennett MJ, Gibson KM, Cohen JC1999 Jan9869665
Structural asymmetry and disulfide bridges among subunits modulate the activity of human malonyl-CoA decarboxylase.Aparicio D, Pérez-Luque R, Carpena X, Díaz M, Ferrer JC, Loewen PC, Fita I2013 Apr 2623482565
Absence of malonyl coenzyme A decarboxylase in mice increases cardiac glucose oxidation and protects the heart from ischemic injury.Dyck JR, Hopkins TA, Bonnet S, Michelakis ED, Young ME, Watanabe M, Kawase Y, Jishage K, Lopaschuk GD2006 Oct 1717030679
Malonyl-CoA decarboxylase is present in the cytosolic, mitochondrial and peroxisomal compartments of rat hepatocytes.Joly E, Bendayan M, Roduit R, Saha AK, Ruderman NB, Prentki M2005 Dec 516298369
Expression, purification, and characterization of human malonyl-CoA decarboxylase.Zhou D, Yuen P, Chu D, Thon V, McConnell S, Brown S, Tsang A, Pena M, Russell A, Cheng JF, Nadzan AM, Barbosa MS, Dyck JR, Lopaschuk GD, Yang G2004 Apr15003260
Rat malonyl-CoA decarboxylase; cloning, expression in E. coli and its biochemical characterization.Lee GY, Bahk YY, Kim YS2002 Mar 3112297032
MCD encodes peroxisomal and cytoplasmic forms of malonyl-CoA decarboxylase and is mutated in malonyl-CoA decarboxylase deficiency.Sacksteder KA, Morrell JC, Wanders RJ, Matalon R, Gould SJ1999 Aug 2710455107
The molecular basis of malonyl-CoA decarboxylase deficiency.FitzPatrick DR, Hill A, Tolmie JL, Thorburn DR, Christodoulou J1999 Aug10417274
Cloning and expression of rat pancreatic beta-cell malonyl-CoA decarboxylase.Voilley N, Roduit R, Vicaretti R, Bonny C, Waeber G, Dyck JR, Lopaschuk GD, Prentki M1999 May 1510229677