EC number:4.1.1.96
| ID: | 4.1.1.96 |
|---|---|
| Description: | Carboxynorspermidine decarboxylase. |
| Alternative Name: |
Carboxyspermidine decarboxylase. |
| Cath: | 3.20.20.10; 2.40.37.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.1.1.96 |
| BRENDA Enzyme Link: | BRENDA 4.1.1.96 |
| KEGG Enzyme Link: | KEGG4.1.1.96 |
| BioCyc Enzyme Link: | BioCyc 4.1.1.96 |
| ExPASy Enzyme Link: | ExPASy4.1.1.96 |
| EC2PDB Enzyme Link: | EC2PDB 4.1.1.96 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.1.1.96 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.1.1.96 |
| IntEnz Enzyme Link: | IntEnz 4.1.1.96 |
| MEDLINE Enzyme Link: | MEDLINE 4.1.1.96 |
| RHEA:34099 | carboxynorspermidine + H(+) = CO2 + norspermidine |
| RULE(radius=1) | [*:1]=[C;H0;+0:2](-[OH;+0:3])-[CH;+0:4](-[*:5])-[*:6].[H+;H0:7]>>[*:5]-[CH2;+0:4]-[*:6].[*:1]=[C;H0;+0:2]=[O;H0;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Evolution of substrate specificity within a diverse family of beta/alpha-barrel-fold basic amino acid decarboxylases: X-ray structure determination of enzymes with specificity for L-arginine and carboxynorspermidine. | Deng X, Lee J, Michael AJ, Tomchick DR, Goldsmith EJ, Phillips MA | 2010 Aug 13 | 20534592 |
| Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota. | Hanfrey CC, Pearson BM, Hazeldine S, Lee J, Gaskin DJ, Woster PM, Phillips MA, Michael AJ | 2011 Dec 16 | 22025614 |
| An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae. | Lee J, Sperandio V, Frantz DE, Longgood J, Camilli A, Phillips MA, Michael AJ | 2009 Apr 10 | 19196710 |
| RHEA:34095 | carboxyspermidine + H(+) = CO2 + spermidine |
| RULE(radius=1) | [*:1]=[C;H0;+0:2](-[OH;+0:3])-[CH;+0:4](-[*:5])-[*:6].[H+;H0:7]>>[*:5]-[CH2;+0:4]-[*:6].[*:1]=[C;H0;+0:2]=[O;H0;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Evolution of substrate specificity within a diverse family of beta/alpha-barrel-fold basic amino acid decarboxylases: X-ray structure determination of enzymes with specificity for L-arginine and carboxynorspermidine. | Deng X, Lee J, Michael AJ, Tomchick DR, Goldsmith EJ, Phillips MA | 2010 Aug 13 | 20534592 |
| Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota. | Hanfrey CC, Pearson BM, Hazeldine S, Lee J, Gaskin DJ, Woster PM, Phillips MA, Michael AJ | 2011 Dec 16 | 22025614 |
| An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae. | Lee J, Sperandio V, Frantz DE, Longgood J, Camilli A, Phillips MA, Michael AJ | 2009 Apr 10 | 19196710 |