EC number:4.1.1.98

Enzyme

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     4. Lyases
        4.1 Carbon-carbon lyases
            4.1.1 Carboxy-lyases
ID:4.1.1.98
Description:4-hydroxy-3-polyprenylbenzoate decarboxylase.
Alternative Name: 4-hydroxy-3-solanesylbenzoate decarboxylase.
3-octaprenyl-4-hydroxybenzoate decarboxylase.
Cath: 1.20.5.570; 3.40.1670.10; 3.40.50.1950;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 4.1.1.98
BRENDA Enzyme Link: BRENDA 4.1.1.98
KEGG Enzyme Link: KEGG4.1.1.98
BioCyc Enzyme Link: BioCyc 4.1.1.98
ExPASy Enzyme Link: ExPASy4.1.1.98
EC2PDB Enzyme Link: EC2PDB 4.1.1.98
ExplorEnz Enzyme Link: ExplorEnz 4.1.1.98
PRIAM enzyme-specific profiles Link: PRIAM 4.1.1.98
IntEnz Enzyme Link: IntEnz 4.1.1.98
MEDLINE Enzyme Link: MEDLINE 4.1.1.98

EC number:4.1.1.98

MSA:

4.1.1.98;
Phylogenetic Tree:

4.1.1.98;
Uniprot:
M-CSA:
RHEA:27778 4-hydroxy-3-all-trans-octaprenylbenzoate + H(+) = 2-all-trans-octaprenylphenol + CO2
RULE(radius=1) [*:1]:[c;H0;+0:2](:[*:3])-[C;H0;+0:4](=[*:5])-[OH;+0:6].[H+;H0:7]>>[*:1]:[cH;+0:2]:[*:3].[*:5]=[C;H0;+0:4]=[O;H0;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction
RHEA:41680 a 4-hydroxy-3-all-trans-polyprenylbenzoate + H(+) = a 2-all-trans-polyprenylphenol + CO2
RULE(radius=1) [*:1]:[c;H0;+0:2](:[*:3])-[C;H0;+0:4](=[*:5])-[OH;+0:6].[H+;H0:7]>>[*:1]:[cH;+0:2]:[*:3].[*:5]=[C;H0;+0:4]=[O;H0;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Membrane-associated reactions in ubiquinone biosynthesis in Escherichia coli. 3-Octaprenyl-4-hydroxybenzoate carboxy-lyase.Leppik RA, Young IG, Gibson F1976 Jul 15782527
Chorismate pyruvate-lyase and 4-hydroxy-3-solanesylbenzoate decarboxylase are required for plastoquinone biosynthesis in the cyanobacterium Synechocystis sp. PCC6803.Pfaff C, Glindemann N, Gruber J, Frentzen M, Sadre R2014 Jan 3124337576
The role of UbiX in Escherichia coli coenzyme Q biosynthesis.Gulmezian M, Hyman KR, Marbois BN, Clarke CF, Javor GT2007 Nov 1517889824
New cofactor supports α,β-unsaturated acid decarboxylation via 1,3-dipolar cycloaddition.Payne KA, White MD, Fisher K, Khara B, Bailey SS, Parker D, Rattray NJ, Trivedi DK, Goodacre R, Beveridge R, Barran P, Rigby SE, Scrutton NS, Hay S, Leys D2015 Jun 2526083754
Isofunctional enzymes PAD1 and UbiX catalyze formation of a novel cofactor required by ferulic acid decarboxylase and 4-hydroxy-3-polyprenylbenzoic acid decarboxylase.Lin F, Ferguson KL, Boyer DR, Lin XN, Marsh EN2015 Apr 1725647642
RHEA:44568 4-hydroxy-3-all-trans-hexaprenylbenzoate + H(+) = 2-all-trans-hexaprenylphenol + CO2
RULE(radius=1) [*:1]:[c;H0;+0:2](:[*:3])-[C;H0;+0:4](=[*:5])-[OH;+0:6].[H+;H0:7]>>[*:1]:[cH;+0:2]:[*:3].[*:5]=[C;H0;+0:4]=[O;H0;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction
RHEA:44572 4-hydroxy-3-all-trans-heptaprenylbenzoate + H(+) = 2-all-trans-heptaprenylphenol + CO2
RULE(radius=1) [*:1]:[c;H0;+0:2](:[*:3])-[C;H0;+0:4](=[*:5])-[OH;+0:6].[H+;H0:7]>>[*:1]:[cH;+0:2]:[*:3].[*:5]=[C;H0;+0:4]=[O;H0;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction
RHEA:44576 4-hydroxy-3-all-trans-nonaprenylbenzoate + H(+) = 2-all-trans-nonaprenylphenol + CO2
RULE(radius=1) [*:1]:[c;H0;+0:2](:[*:3])-[C;H0;+0:4](=[*:5])-[OH;+0:6].[H+;H0:7]>>[*:1]:[cH;+0:2]:[*:3].[*:5]=[C;H0;+0:4]=[O;H0;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction
RHEA:44580 4-hydroxy-3-all-trans-decaprenylbenzoate + H(+) = 2-all-trans-decaprenylphenol + CO2
RULE(radius=1) [*:1]:[c;H0;+0:2](:[*:3])-[C;H0;+0:4](=[*:5])-[OH;+0:6].[H+;H0:7]>>[*:1]:[cH;+0:2]:[*:3].[*:5]=[C;H0;+0:4]=[O;H0;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction