EC number:4.1.1.99
| ID: | 4.1.1.99 |
|---|---|
| Description: | Phosphomevalonate decarboxylase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.1.1.99 |
| BRENDA Enzyme Link: | BRENDA 4.1.1.99 |
| KEGG Enzyme Link: | KEGG4.1.1.99 |
| BioCyc Enzyme Link: | BioCyc 4.1.1.99 |
| ExPASy Enzyme Link: | ExPASy4.1.1.99 |
| EC2PDB Enzyme Link: | EC2PDB 4.1.1.99 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.1.1.99 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.1.1.99 |
| IntEnz Enzyme Link: | IntEnz 4.1.1.99 |
| MEDLINE Enzyme Link: | MEDLINE 4.1.1.99 |
| RHEA:40955 | (R)-5-phosphomevalonate + ATP = ADP + CO2 + isopentenyl phosphate + phosphate |
| RULE(radius=1) | [*:1]=[C;H0;+0:2](-[OH;+0:3])-[CH2;+0:4]-[C;H0;+0:5](-[*:6])(-[*:7])-[OH;+0:8].[*:9]=[P;H0;+0:10](-[*:11])(-[*:12])-[O;H0;+0:13]-[*:14]>>[*:6]-[C;H0;+0:5](-[*:7])=[CH2;+0:4].[*:14]-[OH;+0:13].[*:1]=[C;H0;+0:2]=[O;H0;+0:3].[*:9]=[P;H0;+0:10](-[*:11])(-[*:12])-[OH;+0:8] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Identification in Haloferax volcanii of phosphomevalonate decarboxylase and isopentenyl phosphate kinase as catalysts of the terminal enzyme reactions in an archaeal alternate mevalonate pathway. | Vannice JC, Skaff DA, Keightley A, Addo JK, Wyckoff GJ, Miziorko HM | 2014 Mar | 24375100 |
| Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate. | Grochowski LL, Xu H, White RH | 2006 May | 16621811 |