Enzyme

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     4. Lyases
        4.1 Carbon-carbon lyases
            4.1.2 Aldehyde-lyases
ID:4.1.2.25
Description:Dihydroneopterin aldolase.
Alternative Name: 7,8-dihydroneopterin aldolase.
dihydropteridine glycolaldehyde-lyase.
2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-
Cath: 3.20.20.20; 3.30.1130.10; 3.30.1300.20; 3.30.70.560;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 4.1.2.25
BRENDA Enzyme Link: BRENDA 4.1.2.25
KEGG Enzyme Link: KEGG4.1.2.25
BioCyc Enzyme Link: BioCyc 4.1.2.25
ExPASy Enzyme Link: ExPASy4.1.2.25
EC2PDB Enzyme Link: EC2PDB 4.1.2.25
ExplorEnz Enzyme Link: ExplorEnz 4.1.2.25
PRIAM enzyme-specific profiles Link: PRIAM 4.1.2.25
IntEnz Enzyme Link: IntEnz 4.1.2.25
MEDLINE Enzyme Link: MEDLINE 4.1.2.25
MSA:

4.1.2.25;

Phylogenetic Tree:

4.1.2.25;

Uniprot:
M-CSA:
RHEA:10540 7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[CH;+0:4](-[*:5])-[OH;+0:6]>>[*:1]-[CH2;+0:2]-[*:3].[*:5]-[CH;+0:4]=[O;H0;+0:6]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Biosynthesis of pteridines in Escherichia coli. Structural and mechanistic similarity of dihydroneopterin-triphosphate epimerase and dihydroneopterin aldolase.Haussmann C, Rohdich F, Schmidt E, Bacher A, Richter G1998 Jul 109651328
Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from Staphylococcus aureus.Hennig M, D'Arcy A, Hampele IC, Page MG, Oefner C, Dale GE1998 May9586996
A bifunctional protein in the folate biosynthetic pathway of Streptococcus pneumoniae with dihydroneopterin aldolase and hydroxymethyldihydropterin pyrophosphokinase activities.Lopez P, Lacks SA1993 Apr8385663
The biosynthesis of folic acid. XI. Purification and properties of dihydroneopterin aldolase.Mathis JB, Brown GM1970 Jun 104912541
Crystallographic and molecular dynamics simulation analysis of Escherichia coli dihydroneopterin aldolase.Blaszczyk J, Lu Z, Li Y, Yan H, Ji X201425264482
Biochemical characterization of a dihydroneopterin aldolase used for methanopterin biosynthesis in methanogens.Wang Y, Xu H, Grochowski LL, White RH2014 Sep24982305
One substrate, five products: reactions catalyzed by the dihydroneopterin aldolase from Mycobacterium tuberculosis.Czekster CM, Blanchard JS2012 Dec 523150985
Characterization of the Saccharomyces cerevisiae Fol1 protein: starvation for C1 carrier induces pseudohyphal growth.Güldener U, Koehler GJ, Haussmann C, Bacher A, Kricke J, Becher D, Hegemann JH2004 Aug15169867
Folate biosynthesis in higher plants. cDNA cloning, heterologous expression, and characterization of dihydroneopterin aldolases.Goyer A, Illarionova V, Roje S, Fischer M, Bacher A, Hanson AD2004 May15107504
Biosynthesis of tetrahydrofolate. Stereochemistry of dihydroneopterin aldolase.Illarionova V, Eisenreich W, Fischer M, Haussmann C, Romisch W, Richter G, Bacher A2002 Aug 912039964