EC number:4.1.2.27
| ID: | 4.1.2.27 |
|---|---|
| Description: | Sphinganine-1-phosphate aldolase. |
| Alternative Name: |
Sphingosine-1-phosphate lyase. Sphingosine-1-phosphate aldolase. Sphinganine-1-phosphate palmitaldehyde-lyase. |
| Cath: | 1.10.287.340; 1.10.287.3400; 1.20.5.50; 1.20.5.5080; 3.40.640.10; 3.90.1150.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.1.2.27 |
| BRENDA Enzyme Link: | BRENDA 4.1.2.27 |
| KEGG Enzyme Link: | KEGG4.1.2.27 |
| BioCyc Enzyme Link: | BioCyc 4.1.2.27 |
| ExPASy Enzyme Link: | ExPASy4.1.2.27 |
| EC2PDB Enzyme Link: | EC2PDB 4.1.2.27 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.1.2.27 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.1.2.27 |
| IntEnz Enzyme Link: | IntEnz 4.1.2.27 |
| MEDLINE Enzyme Link: | MEDLINE 4.1.2.27 |
| RHEA:33507 | sphing-4-enine 1-phosphate = (2E)-hexadecenal + phosphoethanolamine |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[OH;+0:3])-[CH;+0:4](-[*:5])-[*:6]>>[*:5]-[CH2;+0:4]-[*:6].[*:1]-[CH;+0:2]=[O;H0;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase. | Saba JD, Nara F, Bielawska A, Garrett S, Hannun YA | 1997 Oct 17 | 9334171 |
| RHEA:18593 | sphinganine 1-phosphate = hexadecanal + phosphoethanolamine |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[OH;+0:3])-[CH;+0:4](-[*:5])-[*:6]>>[*:5]-[CH2;+0:4]-[*:6].[*:1]-[CH;+0:2]=[O;H0;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast. | Zhou J, Saba JD | 1998 Jan 26 | 9464245 |
| The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase. | Saba JD, Nara F, Bielawska A, Garrett S, Hannun YA | 1997 Oct 17 | 9334171 |
| Identification of the phytosphingosine metabolic pathway leading to odd-numbered fatty acids. | Kondo N, Ohno Y, Yamagata M, Obara T, Seki N, Kitamura T, Naganuma T, Kihara A | 2014 Oct 27 | 25345524 |
| Orally active 7-substituted (4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as active-site inhibitors of sphingosine 1-phosphate lyase for the treatment of multiple sclerosis. | Weiler S, Braendlin N, Beerli C, Bergsdorf C, Schubart A, Srinivas H, Oberhauser B, Billich A | 2014 Jun 26 | 24809814 |
| Structure and function of sphingosine-1-phosphate lyase, a key enzyme of sphingolipid metabolism. | Bourquin F, Riezman H, Capitani G, Grütter MG | 2010 Aug 11 | 20696404 |
| Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis. | Reiss U, Oskouian B, Zhou J, Gupta V, Sooriyakumaran P, Kelly S, Wang E, Merrill AH Jr, Saba JD | 2004 Jan 9 | 14570870 |
| Sphingosine phosphate lyase expression is essential for normal development in Caenorhabditis elegans. | Mendel J, Heinecke K, Fyrst H, Saba JD | 2003 Jun 20 | 12682045 |
| Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22(1). | Van Veldhoven PP, Gijsbers S, Mannaerts GP, Vermeesch JR, Brys V | 2000 Sep 27 | 11018465 |
| Sphingosine-1-phosphate lyase. | Van Veldhoven PP | 2000 | 10563331 |