Enzyme

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     4. Lyases
        4.1 Carbon-carbon lyases
            4.1.2 Aldehyde-lyases
ID:4.1.2.4
Description:Deoxyribose-phosphate aldolase.
Alternative Name: Phosphodeoxyriboaldolase.
Deoxyriboaldolase.
2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase.
Cath: 3.20.20.70;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 4.1.2.4
BRENDA Enzyme Link: BRENDA 4.1.2.4
KEGG Enzyme Link: KEGG4.1.2.4
BioCyc Enzyme Link: BioCyc 4.1.2.4
ExPASy Enzyme Link: ExPASy4.1.2.4
EC2PDB Enzyme Link: EC2PDB 4.1.2.4
ExplorEnz Enzyme Link: ExplorEnz 4.1.2.4
PRIAM enzyme-specific profiles Link: PRIAM 4.1.2.4
IntEnz Enzyme Link: IntEnz 4.1.2.4
MEDLINE Enzyme Link: MEDLINE 4.1.2.4
MSA:

4.1.2.4;

Phylogenetic Tree:

4.1.2.4;

Uniprot:
M-CSA:
RHEA:12821 2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate
RULE(radius=1) [*:1]-[CH2;+0:2]-[CH;+0:3](-[*:4])-[OH;+0:5]>>[*:1]-[CH3;+0:2].[*:4]-[CH;+0:3]=[O;H0;+0:5]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Dra-nupC-pdp operon of Bacillus subtilis: nucleotide sequence, induction by deoxyribonucleosides, and transcriptional regulation by the deoR-encoded DeoR repressor protein.Saxild HH, Andersen LN, Hammer K1996 Jan8550462
The primary structure of Escherichia coli K12 2-deoxyribose 5-phosphate aldolase. Nucleotide sequence of the deoC gene and the amino acid sequence of the enzyme.Valentin-Hansen P, Boëtius F, Hammer-Jespersen K, Svendsen I1982 Jul6749498
Deoxyribose-5-P aldolase: subunit structure and composition of active site lysine region.Hoffee P, Snyder P, Sushak C, Jargiello P1974 Oct4618079
DERA is the human deoxyribose phosphate aldolase and is involved in stress response.Salleron L, Magistrelli G, Mary C, Fischer N, Bairoch A, Lane L2014 Dec25229427
Cloning and characterisation of a new 2-deoxy-D-ribose-5-phosphate aldolase from Rhodococcus erythropolis.Kullartz I, Pietruszka J2012 Oct 1522222309
Sequential aldol condensation catalyzed by hyperthermophilic 2-deoxy-d-ribose-5-phosphate aldolase.Sakuraba H, Yoneda K, Yoshihara K, Satoh K, Kawakami R, Uto Y, Tsuge H, Takahashi K, Hori H, Ohshima T2007 Nov17905878
Presence of a novel phosphopentomutase and a 2-deoxyribose 5-phosphate aldolase reveals a metabolic link between pentoses and central carbon metabolism in the hyperthermophilic archaeon Thermococcus kodakaraensis.Rashid N, Imanaka H, Fukui T, Atomi H, Imanaka T2004 Jul15205420
The first crystal structure of archaeal aldolase. Unique tetrameric structure of 2-deoxy-d-ribose-5-phosphate aldolase from the hyperthermophilic archaea Aeropyrum pernix.Sakuraba H, Tsuge H, Shimoya I, Kawakami R, Goda S, Kawarabayasi Y, Katunuma N, Ago H, Miyano M, Ohshima T2003 Mar 2112529358
Observation of covalent intermediates in an enzyme mechanism at atomic resolution.Heine A, DeSantis G, Luz JG, Mitchell M, Wong CH, Wilson IA2001 Oct 1211598300