EC number:4.1.2.52
| ID: | 4.1.2.52 |
|---|---|
| Description: | 4-hydroxy-2-oxoheptanedioate aldolase. |
| Alternative Name: |
HKHD aldolase. HHED aldolase. 4-hydroxy-2-ketoheptanedioate aldolase. 2,4-dihydroxyhept-2-enedioate aldolase. |
| Cath: | 3.20.20.60; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.1.2.52 |
| BRENDA Enzyme Link: | BRENDA 4.1.2.52 |
| KEGG Enzyme Link: | KEGG4.1.2.52 |
| BioCyc Enzyme Link: | BioCyc 4.1.2.52 |
| ExPASy Enzyme Link: | ExPASy4.1.2.52 |
| EC2PDB Enzyme Link: | EC2PDB 4.1.2.52 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.1.2.52 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.1.2.52 |
| IntEnz Enzyme Link: | IntEnz 4.1.2.52 |
| MEDLINE Enzyme Link: | MEDLINE 4.1.2.52 |
| RHEA:25788 | 4-hydroxy-2-oxoheptanedioate = pyruvate + succinate semialdehyde |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[CH;+0:3](-[*:4])-[OH;+0:5]>>[*:1]-[CH3;+0:2].[*:4]-[CH;+0:3]=[O;H0;+0:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Comparison of two metal-dependent pyruvate aldolases related by convergent evolution: substrate specificity, kinetic mechanism, and substrate channeling. | Wang W, Baker P, Seah SY | 2010 May 4 | 20364820 |
| Purification and biochemical characterization of a pyruvate-specific class II aldolase, HpaI. | Wang W, Seah SY | 2005 Jul 12 | 15996099 |