EC number:4.1.2.60
| ID: | 4.1.2.60 |
|---|---|
| Description: | Dihydroneopterin triphosphate aldolase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.1.2.60 |
| BRENDA Enzyme Link: | BRENDA 4.1.2.60 |
| KEGG Enzyme Link: | KEGG4.1.2.60 |
| BioCyc Enzyme Link: | BioCyc 4.1.2.60 |
| ExPASy Enzyme Link: | ExPASy4.1.2.60 |
| EC2PDB Enzyme Link: | EC2PDB 4.1.2.60 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.1.2.60 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.1.2.60 |
| IntEnz Enzyme Link: | IntEnz 4.1.2.60 |
| MEDLINE Enzyme Link: | MEDLINE 4.1.2.60 |
| RHEA:52772 | 7,8-dihydroneopterin 3'-triphosphate = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde triphosphate |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[CH;+0:4](-[*:5])-[OH;+0:6]>>[*:1]-[CH2;+0:2]-[*:3].[*:5]-[CH;+0:4]=[O;H0;+0:6] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| 6-pyruvoyltetrahydropterin synthase paralogs replace the folate synthesis enzyme dihydroneopterin aldolase in diverse bacteria. | Pribat A, Jeanguenin L, Lara-Núñez A, Ziemak MJ, Hyde JE, de Crécy-Lagard V, Hanson AD | 2009 Jul | 19395485 |
| Plasmodium falciparum: a paradigm for alternative folate biosynthesis in diverse microorganisms? | Hyde JE, Dittrich S, Wang P, Sims PF, de Crécy-Lagard V, Hanson AD | 2008 Nov | 18805734 |
| An atypical orthologue of 6-pyruvoyltetrahydropterin synthase can provide the missing link in the folate biosynthesis pathway of malaria parasites. | Dittrich S, Mitchell SL, Blagborough AM, Wang Q, Wang P, Sims PF, Hyde JE | 2008 Feb | 18093090 |