EC number:4.1.2.8

Enzyme

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     4. Lyases
        4.1 Carbon-carbon lyases
            4.1.2 Aldehyde-lyases
ID:4.1.2.8
Description:Indole-3-glycerol-phosphate lyase.
Alternative Name: TSA.
Tryptophan synthase alpha.
Indoleglycerolphosphate aldolase.
Indole-3-glycerolphosphate D-glyceraldehyde-3-phosphate-lyase.
Indole-3-glycerol phosphate lyase.
Indole synthase.
Indole glycerol phosphate hydrolase.
phosphate-lyase.
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3-
Prosite: PDOC00151;
PDB:
PDBScop
1WDW 8030882; 8043261; 8030882; 8043261; 8030882; 8043261; 8020673; 8033053; 8020673; 8033053; 8020673; 8033053; 8030882; 8043261; 8030882; 8043261; 8030882; 8043261; 8020673; 8033053; 8020673; 8033053; 8020673; 8033053;
2E09 8030882; 8043261; 8030882; 8043261;
2DZX 8030882; 8043261; 8030882; 8043261;
2DZW 8030882; 8043261; 8030882; 8043261;
2DZV 8030882; 8043261; 8030882; 8043261;
 » show all
Cath: 3.20.20.70; 3.40.50.1100;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 4.1.2.8
BRENDA Enzyme Link: BRENDA 4.1.2.8
KEGG Enzyme Link: KEGG4.1.2.8
BioCyc Enzyme Link: BioCyc 4.1.2.8
ExPASy Enzyme Link: ExPASy4.1.2.8
EC2PDB Enzyme Link: EC2PDB 4.1.2.8
ExplorEnz Enzyme Link: ExplorEnz 4.1.2.8
PRIAM enzyme-specific profiles Link: PRIAM 4.1.2.8
IntEnz Enzyme Link: IntEnz 4.1.2.8
MEDLINE Enzyme Link: MEDLINE 4.1.2.8

EC number:4.1.2.8

MSA:

4.1.2.8;
Phylogenetic Tree:

4.1.2.8;
Uniprot:
M-CSA:
RHEA:14081 (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = D-glyceraldehyde 3-phosphate + indole
RULE(radius=1) [*:1]:[c;H0;+0:2](:[*:3])-[CH;+0:4](-[*:5])-[OH;+0:6]>>[*:5]-[CH;+0:4]=[O;H0;+0:6].[*:1]:[cH;+0:2]:[*:3]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Three-dimensional structure of the tryptophan synthase alpha 2 beta 2 multienzyme complex from Salmonella typhimurium.Hyde CC, Ahmed SA, Padlan EA, Miles EW, Davies DR1988 Nov 253053720
ON THE SEPARATION OF THE TRYPTOPHAN SYNTHETASE OF ESCHERICHIA COLI INTO TWO PROTEIN COMPONENTS.Crawford IP, Yanofsky C1958 Dec 1516590328
Proteomic survey of copper-binding proteins in Arabidopsis roots by immobilized metal affinity chromatography and mass spectrometry.Kung CC, Huang WN, Huang YC, Yeh KC2006 May16526091
Mechanisms of monovalent cation action in enzyme catalysis: the tryptophan synthase alpha-, beta-, and alpha beta-reactions.Woehl E, Dunn MF1999 Jun 110353823