EC number:4.1.3.1
| ID: | 4.1.3.1 |
|---|---|
| Description: | Isocitrate lyase. |
| Alternative Name: |
Isocitritase. Isocitrate glyoxylate-lyase. Isocitratase. Isocitrase. ICL. |
| Prosite: | PDOC00145; |
| PDB: |
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| Cath: | 1.10.10.850; 3.20.20.60; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.1.3.1 |
| BRENDA Enzyme Link: | BRENDA 4.1.3.1 |
| KEGG Enzyme Link: | KEGG4.1.3.1 |
| BioCyc Enzyme Link: | BioCyc 4.1.3.1 |
| ExPASy Enzyme Link: | ExPASy4.1.3.1 |
| EC2PDB Enzyme Link: | EC2PDB 4.1.3.1 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.1.3.1 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.1.3.1 |
| IntEnz Enzyme Link: | IntEnz 4.1.3.1 |
| MEDLINE Enzyme Link: | MEDLINE 4.1.3.1 |
| RHEA:13245 | isocitrate = glyoxylate + succinate |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[OH;+0:3])-[CH;+0:4](-[*:5])-[*:6]>>[*:5]-[CH2;+0:4]-[*:6].[*:1]-[CH;+0:2]=[O;H0;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Characterization, gene cloning and expression of isocitrate lyase involved in the assimilation of one-carbon compounds in Hyphomicrobium methylovorum GM2. | Tanaka Y, Yoshida T, Watanabe K, Izumi Y, Mitsunaga T | 1997 Nov 1 | 9395332 |
| The importance of four histidine residues in isocitrate lyase from Escherichia coli. | Diehl P, McFadden BA | 1994 Feb | 8300547 |
| Characterization of the isocitrate lyase gene from Corynebacterium glutamicum and biochemical analysis of the enzyme. | Reinscheid DJ, Eikmanns BJ, Sahm H | 1994 Jun | 8206824 |
| Cysteine is the general base that serves in catalysis by isocitrate lyase and in mechanism-based inhibition by 3-nitropropionate. | Moynihan MM, Murkin AS | 2014 Jan 14 | 24354272 |
| Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis. | Sharma V, Sharma S, Hoener zu Bentrup K, McKinney JD, Russell DG, Jacobs WR Jr, Sacchettini JC | 2000 Aug | 10932251 |
| The crystal structure and active site location of isocitrate lyase from the fungus Aspergillus nidulans. | Britton K, Langridge S, Baker PJ, Weeradechapon K, Sedelnikova SE, De Lucas JR, Rice DW, Turner G | 2000 Apr 15 | 10801489 |
| Characterization of activity and expression of isocitrate lyase in Mycobacterium avium and Mycobacterium tuberculosis. | Höner Zu Bentrup K, Miczak A, Swenson DL, Russell DG | 1999 Dec | 10572116 |