EC number:4.1.3.16
| ID: | 4.1.3.16 | ||
|---|---|---|---|
| Description: | 4-hydroxy-2-oxoglutarate aldolase. | ||
| Alternative Name: |
KHGA. KHG-aldolase. 4-hydroxy-2-oxoglutarate glyoxylate-lyase. 2-oxo-4-hydroxyglutarate aldolase. 2-keto-4-hydroxyglutarate aldolase. | ||
| Prosite: | PDOC00144; | ||
| PDB: |
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| Cath: | 3.20.20.70; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.1.3.16 |
| BRENDA Enzyme Link: | BRENDA 4.1.3.16 |
| KEGG Enzyme Link: | KEGG4.1.3.16 |
| BioCyc Enzyme Link: | BioCyc 4.1.3.16 |
| ExPASy Enzyme Link: | ExPASy4.1.3.16 |
| EC2PDB Enzyme Link: | EC2PDB 4.1.3.16 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.1.3.16 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.1.3.16 |
| IntEnz Enzyme Link: | IntEnz 4.1.3.16 |
| MEDLINE Enzyme Link: | MEDLINE 4.1.3.16 |
| RHEA:18169 | 4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](=[*:3])-[CH2;+0:4]-[CH;+0:5](-[*:6])-[OH;+0:7]>>[*:6]-[C;H0;+0:5](-[CH3;+0:4])=[O;H0;+0:7].[*:1]-[CH;+0:2]=[*:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Regulation of rat liver 4-hydroxy-2-ketoglutarate aldolase. | Scholtz JM, Schuster SM | 1986 Jan 30 | 3942759 |
| Purification and properties of 4-hydroxy-4-methyl-2-oxoglutarate aldolase from Pseudomonas ochraceae grown on phthalate. | Maruyama K | 1990 Aug | 2229032 |
| Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluria. | Riedel TJ, Johnson LC, Knight J, Hantgan RR, Holmes RP, Lowther WT | 2011 | 21998747 |
| Characterization and crystal structure of Escherichia coli KDPGal aldolase. | Walters MJ, Srikannathasan V, McEwan AR, Naismith JH, Fierke CA, Toone EJ | 2008 Jan 15 | 17981470 |
| Cloning, sequencing, and expression of the gene encoding 4-hydroxy-4-methyl-2-oxoglutarate aldolase from Pseudomonas ochraceae NGJ1. | Maruyama K, Miwa M, Tsujii N, Nagai T, Tomita N, Harada T, Sobajima H, Sugisaki H | 2001 Dec | 11826967 |