EC number:4.1.3.17
| ID: | 4.1.3.17 |
|---|---|
| Description: | 4-hydroxy-4-methyl-2-oxoglutarate aldolase. |
| Alternative Name: |
HMG aldolase. CHA aldolase. 4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase. 4-carboxy-4-hydroxy-2-oxoadipate aldolase. |
| Cath: | 3.50.30.10; 3.50.30.100; 3.50.30.40; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.1.3.17 |
| BRENDA Enzyme Link: | BRENDA 4.1.3.17 |
| KEGG Enzyme Link: | KEGG4.1.3.17 |
| BioCyc Enzyme Link: | BioCyc 4.1.3.17 |
| ExPASy Enzyme Link: | ExPASy4.1.3.17 |
| EC2PDB Enzyme Link: | EC2PDB 4.1.3.17 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.1.3.17 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.1.3.17 |
| IntEnz Enzyme Link: | IntEnz 4.1.3.17 |
| MEDLINE Enzyme Link: | MEDLINE 4.1.3.17 |
| RHEA:28935 | 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = oxaloacetate + pyruvate |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3])(-[OH;+0:4])-[CH2;+0:5]-[*:6]>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:6]-[CH3;+0:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and properties of 4-hydroxy-4-methyl-2-oxoglutarate aldolase from Pseudomonas ochraceae grown on phthalate. | Maruyama K | 1990 Aug | 2229032 |
| Purification and properties of 2-pyrone-4,6-dicarboxylate hydrolase. | Maruyama K | 1983 Feb | 6841353 |
| Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida. | Nogales J, Canales A, Jiménez-Barbero J, Serra B, Pingarrón JM, García JL, Díaz E | 2011 Jan | 21219457 |
| Absolute configuration of a metabolite in the m-fission pathway of protocatechuate. | Ritter CS, Chapman PJ, Dagley S | 1973 Feb | 4347922 |
| 4-Hydroxy-4-methyl-2-ketoglutarate aldolase from Pseudomonas putida. | Dagley S | 1982 | 7154956 |
| Purification and properties of 4-hydroxy-4-methyl-2-oxoglutarate aldolase. | Tack BF, Chapman PJ, Dagley S | 1972 Oct 25 | 5076765 |
| RHEA:22748 | 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3])(-[OH;+0:4])-[CH2;+0:5]-[*:6]>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:6]-[CH3;+0:5] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification and properties of 4-hydroxy-4-methyl-2-oxoglutarate aldolase from Pseudomonas ochraceae grown on phthalate. | Maruyama K | 1990 Aug | 2229032 |
| Cloning, sequencing, and expression of the gene encoding 4-hydroxy-4-methyl-2-oxoglutarate aldolase from Pseudomonas ochraceae NGJ1. | Maruyama K, Miwa M, Tsujii N, Nagai T, Tomita N, Harada T, Sobajima H, Sugisaki H | 2001 Dec | 11826967 |
| Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida. | Nogales J, Canales A, Jiménez-Barbero J, Serra B, Pingarrón JM, García JL, Díaz E | 2011 Jan | 21219457 |
| 4-Hydroxy-4-methyl-2-ketoglutarate aldolase from Pseudomonas putida. | Dagley S | 1982 | 7154956 |
| Purification and properties of 4-hydroxy-4-methyl-2-oxoglutarate aldolase. | Tack BF, Chapman PJ, Dagley S | 1972 Oct 25 | 5076765 |
| Biochemical and structural analysis of RraA proteins to decipher their relationships with 4-hydroxy-4-methyl-2-oxoglutarate/4-carboxy-4-hydroxy-2-oxoadipate aldolases. | Mazurkewich S, Wang W, Seah SY | 2014 Jan 28 | 24359411 |