EC number:4.1.3.24
| ID: | 4.1.3.24 |
|---|---|
| Description: | Malyl-CoA lyase. |
| Alternative Name: |
Malyl-coenzyme A lyase. L-malyl-CoA lyase. (3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase. |
| Cath: | 3.20.20.60; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.1.3.24 |
| BRENDA Enzyme Link: | BRENDA 4.1.3.24 |
| KEGG Enzyme Link: | KEGG4.1.3.24 |
| BioCyc Enzyme Link: | BioCyc 4.1.3.24 |
| ExPASy Enzyme Link: | ExPASy4.1.3.24 |
| EC2PDB Enzyme Link: | EC2PDB 4.1.3.24 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.1.3.24 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.1.3.24 |
| IntEnz Enzyme Link: | IntEnz 4.1.3.24 |
| MEDLINE Enzyme Link: | MEDLINE 4.1.3.24 |
| RHEA:38259 | (2R,3S)-beta-methylmalyl-CoA = glyoxylate + propanoyl-CoA |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[OH;+0:3])-[CH;+0:4](-[*:5])-[*:6]>>[*:5]-[CH2;+0:4]-[*:6].[*:1]-[CH;+0:2]=[O;H0;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A methylaspartate cycle in haloarchaea. | Khomyakova M, Bükmez Ö, Thomas LK, Erb TJ, Berg IA | 2011 Jan 21 | 21252347 |
| The apparent malate synthase activity of Rhodobacter sphaeroides is due to two paralogous enzymes, (3S)-Malyl-coenzyme A (CoA)/{beta}-methylmalyl-CoA lyase and (3S)- Malyl-CoA thioesterase. | Erb TJ, Frerichs-Revermann L, Fuchs G, Alber BE | 2010 Mar | 20047909 |
| Properties of R-citramalyl-coenzyme A lyase and its role in the autotrophic 3-hydroxypropionate cycle of Chloroflexus aurantiacus. | Friedmann S, Alber BE, Fuchs G | 2007 Apr | 17259315 |
| L-malyl-coenzyme A/beta-methylmalyl-coenzyme A lyase is involved in acetate assimilation of the isocitrate lyase-negative bacterium Rhodobacter capsulatus. | Meister M, Saum S, Alber BE, Fuchs G | 2005 Feb | 15687206 |
| ENZYMIC CLEAVAGE OF MALYTL-COENZYME A INTO ACETYL-COENZYME A AND GLYOXYLIC ACID. | TUBOI S, KIKUCHI G | 1965 Jan | 14285256 |
| L-Malyl-coenzyme A lyase/beta-methylmalyl-coenzyme A lyase from Chloroflexus aurantiacus, a bifunctional enzyme involved in autotrophic CO(2) fixation. | Herter S, Busch A, Fuchs G | 2002 Nov | 12374834 |
| RHEA:16629 | (S)-malyl-CoA = acetyl-CoA + glyoxylate |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[OH;+0:3])-[CH2;+0:4]-[*:5]>>[*:5]-[CH3;+0:4].[*:1]-[CH;+0:2]=[O;H0;+0:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Malyl coenzyme A lyase. Mechanism of action as deduced by kinetic analysis. | Hersh LB | 1974 Aug 25 | 4853084 |
| A methylaspartate cycle in haloarchaea. | Khomyakova M, Bükmez Ö, Thomas LK, Erb TJ, Berg IA | 2011 Jan 21 | 21252347 |
| The apparent malate synthase activity of Rhodobacter sphaeroides is due to two paralogous enzymes, (3S)-Malyl-coenzyme A (CoA)/{beta}-methylmalyl-CoA lyase and (3S)- Malyl-CoA thioesterase. | Erb TJ, Frerichs-Revermann L, Fuchs G, Alber BE | 2010 Mar | 20047909 |
| Properties of R-citramalyl-coenzyme A lyase and its role in the autotrophic 3-hydroxypropionate cycle of Chloroflexus aurantiacus. | Friedmann S, Alber BE, Fuchs G | 2007 Apr | 17259315 |
| L-malyl-coenzyme A/beta-methylmalyl-coenzyme A lyase is involved in acetate assimilation of the isocitrate lyase-negative bacterium Rhodobacter capsulatus. | Meister M, Saum S, Alber BE, Fuchs G | 2005 Feb | 15687206 |
| ENZYMIC CLEAVAGE OF MALYTL-COENZYME A INTO ACETYL-COENZYME A AND GLYOXYLIC ACID. | TUBOI S, KIKUCHI G | 1965 Jan | 14285256 |
| L-Malyl-coenzyme A lyase/beta-methylmalyl-coenzyme A lyase from Chloroflexus aurantiacus, a bifunctional enzyme involved in autotrophic CO(2) fixation. | Herter S, Busch A, Fuchs G | 2002 Nov | 12374834 |