EC number:4.1.3.30
| ID: | 4.1.3.30 |
|---|---|
| Description: | Methylisocitrate lyase. |
| Alternative Name: |
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase. |
| Cath: | 1.10.10.850; 3.20.20.60; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.1.3.30 |
| BRENDA Enzyme Link: | BRENDA 4.1.3.30 |
| KEGG Enzyme Link: | KEGG4.1.3.30 |
| BioCyc Enzyme Link: | BioCyc 4.1.3.30 |
| ExPASy Enzyme Link: | ExPASy4.1.3.30 |
| EC2PDB Enzyme Link: | EC2PDB 4.1.3.30 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.1.3.30 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.1.3.30 |
| IntEnz Enzyme Link: | IntEnz 4.1.3.30 |
| MEDLINE Enzyme Link: | MEDLINE 4.1.3.30 |
| RHEA:16809 | (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3])(-[OH;+0:4])-[CH;+0:5](-[*:6])-[*:7]>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:6]-[CH2;+0:5]-[*:7] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Purification of isocitrate lyase from Saccharomyces cerevisiae. | Lopez-Boado YS, Herrero P, Fernandez MT, Fernandez R, Moreno F | 1988 Mar | 3059712 |
| Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis. | Gould TA, van de Langemheen H, Muñoz-Elías EJ, McKinney JD, Sacchettini JC | 2006 Aug | 16879647 |
| Crystal structures of 2-methylisocitrate lyase in complex with product and with isocitrate inhibitor provide insight into lyase substrate specificity, catalysis and evolution. | Liu S, Lu Z, Han Y, Melamud E, Dunaway-Mariano D, Herzberg O | 2005 Mar 1 | 15723538 |
| Residues C123 and D58 of the 2-methylisocitrate lyase (PrpB) enzyme of Salmonella enterica are essential for catalysis. | Grimek TL, Holden H, Rayment I, Escalante-Semerena JC | 2003 Aug | 12897003 |
| 2-Methylisocitrate lyases from the bacterium Escherichia coli and the filamentous fungus Aspergillus nidulans: characterization and comparison of both enzymes. | Brock M, Darley D, Textor S, Buckel W | 2001 Jun | 11422389 |
| In vitro conversion of propionate to pyruvate by Salmonella enterica enzymes: 2-methylcitrate dehydratase (PrpD) and aconitase Enzymes catalyze the conversion of 2-methylcitrate to 2-methylisocitrate. | Horswill AR, Escalante-Semerena JC | 2001 Apr 17 | 11294638 |