EC number:4.1.99.11
| ID: | 4.1.99.11 |
|---|---|
| Description: | Benzylsuccinate synthase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 4.1.99.11 |
| BRENDA Enzyme Link: | BRENDA 4.1.99.11 |
| KEGG Enzyme Link: | KEGG4.1.99.11 |
| BioCyc Enzyme Link: | BioCyc 4.1.99.11 |
| ExPASy Enzyme Link: | ExPASy4.1.99.11 |
| EC2PDB Enzyme Link: | EC2PDB 4.1.99.11 |
| ExplorEnz Enzyme Link: | ExplorEnz 4.1.99.11 |
| PRIAM enzyme-specific profiles Link: | PRIAM 4.1.99.11 |
| IntEnz Enzyme Link: | IntEnz 4.1.99.11 |
| MEDLINE Enzyme Link: | MEDLINE 4.1.99.11 |
EC number:4.1.99.11
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:10416 | fumarate + toluene = 2-benzylsuccinate |
| RULE(radius=1) | [*:1]-[CH3;+0:2].[*:3]-[CH;+0:4]=[CH;+0:5]-[*:6]>>[*:1]-[CH2;+0:2]-[CH;+0:5](-[*:6])-[CH2;+0:4]-[*:3] |
| Reaction |  |
| Core-to-Core | No scaffolds atoms were exchanged as a result of the reaction |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Analysis of the novel benzylsuccinate synthase reaction for anaerobic toluene activation based on structural studies of the product. | Beller HR, Spormann AM | 1998 Oct | 9765580 |
| Biochemical and genetic characterization of benzylsuccinate synthase from Thauera aromatica: a new glycyl radical enzyme catalysing the first step in anaerobic toluene metabolism. | Leuthner B, Leutwein C, Schulz H, Hörth P, Haehnel W, Schiltz E, Schägger H, Heider J | 1998 May | 9632263 |
| Anaerobic activation of toluene and o-xylene by addition to fumarate in denitrifying strain T. | Beller HR, Spormann AM | 1997 Feb | 9006019 |
| Evidence that anaerobic oxidation of toluene in the denitrifying bacterium Thauera aromatica is initiated by formation of benzylsuccinate from toluene and fumarate. | Biegert T, Fuchs G, Heider J | 1996 Jun 15 | 8706665 |
| Insights into the glycyl radical enzyme active site of benzylsuccinate synthase: a computational study. | Bharadwaj VS, Dean AM, Maupin CM | 2013 Aug 21 | 23865732 |
| Deuterium isotope effects in the unusual addition of toluene to fumarate catalyzed by benzylsuccinate synthase. | Li L, Marsh EN | 2006 Nov 21 | 17105211 |
| A stable organic free radical in anaerobic benzylsuccinate synthase of Azoarcus sp. strain T. | Krieger CJ, Roseboom W, Albracht SP, Spormann AM | 2001 Apr 20 | 11278506 |
| Phototrophic utilization of toluene under anoxic conditions by a new strain of blastochloris sulfoviridis | Zengler K, Heider J, Rossello-Mora R, Widdel F | 1999 Oct | 10525736 |