Enzyme

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     4. Lyases
        4.1 Carbon-carbon lyases
            4.1.99 Other carbon-carbon lyases
ID:4.1.99.12
Description:3,4-dihydroxy-2-butanone-4-phosphate synthase.
Alternative Name: L-3,4-dihydroxybutan-2-one-4-phosphate synthase.
DHBP synthase.
Cath: 3.90.870.10; 3.40.50.10990;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 4.1.99.12
BRENDA Enzyme Link: BRENDA 4.1.99.12
KEGG Enzyme Link: KEGG4.1.99.12
BioCyc Enzyme Link: BioCyc 4.1.99.12
ExPASy Enzyme Link: ExPASy4.1.99.12
EC2PDB Enzyme Link: EC2PDB 4.1.99.12
ExplorEnz Enzyme Link: ExplorEnz 4.1.99.12
PRIAM enzyme-specific profiles Link: PRIAM 4.1.99.12
IntEnz Enzyme Link: IntEnz 4.1.99.12
MEDLINE Enzyme Link: MEDLINE 4.1.99.12
MSA:

4.1.99.12;

Phylogenetic Tree:

4.1.99.12;

Uniprot:
M-CSA:
RHEA:18457 D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)
RULE(radius=1) [*:1]-[CH2;+0:2]-[C;H0;+0:3](=[O;H0;+0:4])-[CH;+0:5](-[*:6])-[OH;+0:7]>>[*:6]-[C;H0;+0:5](-[CH3;+0:3])=[O;H0;+0:7].[*:1]-[CH;+0:2]=[O;H0;+0:4]
Reaction
Core-to-Core No scaffolds atoms were exchanged as a result of the reaction

References

TitleAuthorsDatePubMed ID
Studies on the 4-carbon precursor in the biosynthesis of riboflavin. Purification and properties of L-3,4-dihydroxy-2-butanone-4-phosphate synthase.Volk R, Bacher A1990 Nov 152246238
Potential anti-infective targets in pathogenic yeasts: structure and properties of 3,4-dihydroxy-2-butanone 4-phosphate synthase of Candida albicans.Echt S, Bauer S, Steinbacher S, Huber R, Bacher A, Fischer M2004 Aug 2015328619
Metal sites in 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with the substrate ribulose 5-phosphate.Steinbacher S, Schiffmann S, Bacher A, Fischer M2004 Jul15213409
Structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with divalent metal ions and the substrate ribulose 5-phosphate: implications for the catalytic mechanism.Steinbacher S, Schiffmann S, Richter G, Huber R, Bacher A, Fischer M2003 Oct 2412904291
Biosynthesis of riboflavin in archaea studies on the mechanism of 3,4-dihydroxy-2-butanone-4-phosphate synthase of Methanococcus jannaschii.Fischer M, Romisch W, Schiffmann S, Kelly M, Oschkinat H, Steinbacher S, Huber R, Eisenreich W, Richter G, Bacher A2002 Nov 112200440
Structural definition of the active site and catalytic mechanism of 3,4-dihydroxy-2-butanone-4-phosphate synthase.Liao DI, Zheng YJ, Viitanen PV, Jordan DB2002 Feb 1211827524
The NMR structure of the 47-kDa dimeric enzyme 3,4-dihydroxy-2-butanone-4-phosphate synthase and ligand binding studies reveal the location of the active site.Kelly MJ, Ball LJ, Krieger C, Yu Y, Fischer M, Schiffmann S, Schmieder P, Kühne R, Bermel W, Bacher A, Richter G, Oschkinat H2001 Nov 611687623
Crystal structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase of riboflavin biosynthesis.Liao DI, Calabrese JC, Wawrzak Z, Viitanen PV, Jordan DB2001 Jan 1011342130